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eIF4EBP1 抗体 (pThr45)

Name: eIF4EBP1 抗体 (pThr45)
SKU: ABIN362266
Availability: OutOfStock

EIF4EBP1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

(1 reference)

产品编号 ABIN362266

发货至: 中国

Datasheet as PDF

抗原 See all eIF4EBP1 (EIF4EBP1) 抗体

eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))
抗原表位
29

28

26

21

16

15

12

11

11

9

8

7

6

5

5

4

4

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

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1

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1

1

1

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1

1

1

1

1

1
pThr45
适用
237

165

121

21

14

7

6

5

4

3

2

2

1

1

1
人, 小鼠, 大鼠
宿主
256

13

4
兔
Compatible Secondaries
克隆类型
237

38
多克隆
标记
116

25

18

11

10

10

10

9

9

9

7

6

6

6

6

6

5

1

1

1

1

1

1
This eIF4EBP1 antibody is un-conjugated
应用范围
217

90

87

67

66

46

30

23

16

12

10

8

5

3

2

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

特异性

The antibody detects endogenous level of 4E-BP1 only when phosphorylated at Threonine 45.

纯化方法

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

免疫原

Peptide sequence around phosphorylation site of pThr45 (S-T-T (p) -P-G) derived from Human 4E-BP1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

亚型

IgG

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anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) antibody
EIF4EBP1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (pThr37), (pThr46) antibody
EIF4EBP1 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (C-Term) antibody
EIF4EBP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (pSer65) antibody
EIF4EBP1 适用: 人 WB, IHC, ELISA, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 1E2E7 unconjugated

anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (pSer65) antibody
EIF4EBP1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (AA 1-118) antibody
EIF4EBP1 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 4F3-H2 unconjugated

anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (pThr36) antibody
EIF4EBP1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (AA 2-111) antibody
EIF4EBP1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (AA 2-118) antibody
EIF4EBP1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (Thr69) antibody
EIF4EBP1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C/-20 °C

储存方法

Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Cao, Gong, Guo, Mietzsch, Kuang, Kwartler, Safi, Estrera, Gambello, Milewicz: "Thoracic aortic disease in tuberous sclerosis complex: molecular pathogenesis and potential therapies in Tsc2+/- mice." in: Human molecular genetics, Vol. 19, Issue 10, pp. 1908-20, (2010) (PubMed).
抗原

eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))

别名

4E-BP1 (EIF4EBP1 产品)

别名

4E-BP1 antibody, 4EBP1 antibody, BP-1 antibody, PHAS-I antibody, 4e-bp1 antibody, AA959816 antibody, 153432_at antibody, 43-BP antibody, 4E-BP antibody, 4EBP antibody, 4e-bp antibody, 4eBP antibody, 4ebp antibody, BcDNA.HL08053 antibody, BcDNA:HL08053 antibody, CG8846 antibody, CT8705 antibody, Dm 4E-BP antibody, Dmel\\CG8846 antibody, Phas1 antibody, Thor/EIF4EBP antibody, anon-WO0172774.158 antibody, d4E-BP antibody, d4E-BP1 antibody, d4EBP antibody, d4e-bp antibody, d4eBP antibody, dthor antibody, eIF4E-BP antibody, l(2)06270 antibody, l(2)k07736 antibody, l(2)k13517 antibody, pp20 antibody, thor antibody, EIF4EBP1 antibody, fc04h09 antibody, wu:fc04h09 antibody, zgc:64137 antibody, eukaryotic translation initiation factor 4E binding protein 1 antibody, CG8846 gene product from transcript CG8846-RA antibody, EIF4EBP1 antibody, Eif4ebp1 antibody, Thor antibody, eif4ebp1 antibody

背景

4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. Published Papers Jiumei Cao

分子量

18 kDa

NCBI登录号

NP_004086

UniProt

Q13541

途径

MAPK Pathway, PI3K-Akt Signaling, RTK signaling, AMPK Signaling, Regulation of Cell Size, BCR Signaling