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CRYAB 抗体

CRYAB 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN361836
发货至: 中国
  • 抗原 See all CRYAB 抗体
    CRYAB (Crystallin, alpha B (CRYAB))
    适用
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    宿主
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    克隆类型
    • 152
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    多克隆
    标记
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    This CRYAB antibody is un-conjugated
    应用范围
    • 140
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    Detects ~22 kDa. Does not cross-react with αA-crystallin.
    交叉反应
    小鸡, Cow, 人, 小鼠, 大鼠
    纯化方法
    Affinity Purified
    免疫原
    Synthetic peptide corresponding to human alpha B crystallin conjugated to KLH
    Top Product
    Discover our top product CRYAB Primary Antibody
  • 应用备注
    • WB (1:5000)
    • ICC/IF (1:120)
    • optimal dilutions for assays should be determined by the user.
    说明

    A 1:5000 dilution of ABIN361836 was sufficient for detection of alpha B crystallin in 20 μg of HeLa cell lysate by ECL immunoblot analysis.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C
  • 抗原
    CRYAB (Crystallin, alpha B (CRYAB))
    别名
    Alpha B Crystallin (CRYAB 产品)
    别名
    CMD1II antibody, CRYA2 antibody, CTPP2 antibody, CTRCT16 antibody, HSPB5 antibody, MFM2 antibody, Crya-2 antibody, Crya2 antibody, HspB5 antibody, AACRYA antibody, CRYAB antibody, cryab antibody, cryab2 antibody, wu:fe37f08 antibody, zgc:91937 antibody, crystallin alpha B antibody, crystallin, alpha B antibody, hypothetical protein antibody, crystallin, alpha B, a antibody, crystallin, alpha B, b antibody, CRYAB antibody, Cryab antibody, ZK1128.7 antibody, cryaba antibody, cryabb antibody
    背景
    The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with HSP25 and HSP27 (1). Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance (2). In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases (8). Specifically, alpha-B cystallin is found in many cells and organs outside the lens, and alpha B is overexpressed in several neurological disorders and in cell lines under stress conditions (9).
    基因ID
    1410
    NCBI登录号
    NP_001876
    UniProt
    P02511
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