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CDK5R1 抗体

CDK5R1 适用: 人 WB, ELISA, IHC, IF, IP, ICC, AA 宿主: 小鼠 Monoclonal JJ6 unconjugated
产品编号 ABIN361805
发货至: 中国
  • 抗原 See all CDK5R1 抗体
    CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
    适用
    • 60
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    • 5
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    宿主
    • 52
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    小鼠
    克隆类型
    • 46
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    单克隆
    标记
    • 25
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    This CDK5R1 antibody is un-conjugated
    应用范围
    • 60
    • 43
    • 39
    • 21
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    • 12
    • 10
    • 10
    • 5
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Antibody Array (AA)
    特异性
    Detects ~23 kDa.
    交叉反应
    小鸡, 豚鼠, 人, 小鼠, 兔, Saccharomyces cerevisiae
    纯化方法
    Protein G Purified
    免疫原
    Recombinant human full length p23 protein
    克隆位点
    JJ6
    亚型
    IgG1
  • 应用备注
    • WB (1:2000) IHC (1:100)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    说明

    0.5 μg/ml of ABIN361804 was sufficient for detection of p23 in 20 μg of heat shocked cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C
  • Shimamura, Perera, Foley, Sang, Rodig, Inoue, Chen, Li, Carretero, Li, Sinha, Carey, Borgman, Jimenez, Meyerson, Ying, Barsoum, Wong, Shapiro: "Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 18, pp. 4973-85, (2012) (PubMed).

  • 抗原
    CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
    别名
    p23 (CDK5R1 产品)
    别名
    CDK5P35 antibody, CDK5R antibody, NCK5A antibody, p23 antibody, p25 antibody, p35 antibody, p35nck5a antibody, cdk5r1 antibody, zgc:92814 antibody, CDK5R1 antibody, Cdk5r antibody, P25/P35 antibody, D11Bwg0379e antibody, Xp35.1 antibody, cyclin dependent kinase 5 regulatory subunit 1 antibody, cyclin-dependent kinase 5, regulatory subunit 1b (p35) antibody, cyclin-dependent kinase 5 regulatory subunit 1 antibody, S100 calcium binding protein A9 antibody, cyclin-dependent kinase 5, regulatory subunit 1 (p35) antibody, cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog antibody, CDK5R1 antibody, cdk5r1b antibody, Cdk5r1 antibody, S100A9 antibody, cdk5r1.L antibody
    背景
    P23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the HSP90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 does not have any structural homology with any other known proteins (1). p23 was first discovered as a part of the HSP90-progesterone receptor complex along with HSP70, p54 and p50 (1). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate-mediated HSP90 binding of client proteins (8). Since many HSP90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). HSP90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.
    基因ID
    10728
    NCBI登录号
    NP_006592
    UniProt
    Q15185
    途径
    Stem Cell Maintenance, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity
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