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LAMP1 抗体

LAMP1 适用: 大鼠 WB, IF, IP, ICC 宿主: 小鼠 Monoclonal Ly1C6 unconjugated
产品编号 ABIN361796
发货至: 中国
  • 抗原 See all LAMP1 抗体
    LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
    适用
    • 93
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    大鼠
    宿主
    • 56
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    • 1
    小鼠
    克隆类型
    • 80
    • 48
    单克隆
    标记
    • 48
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    This LAMP1 antibody is un-conjugated
    应用范围
    • 87
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    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    特异性
    Detects ~120 kDa.
    交叉反应
    Hamster, 人, 小鼠, 大鼠
    纯化方法
    Protein G Purified
    免疫原
    Rat liver lysosomal membrane preparations
    克隆位点
    Ly1C6
    亚型
    IgG1
    Top Product
    Discover our top product LAMP1 Primary Antibody
  • 应用备注
    • WB (1:1000)
    • ICC/IF (1:1000)
    • optimal dilutions for assays should be determined by the user.
    说明

    1 μg/ml was sufficient for detection of LAMP1 in rat liver miscrosome by ECL immunoblot analysis.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    -20°C
  • Harada, Hiasa: "Immunological identification of vesicular nucleotide transporter in intestinal L cells." in: Biological & pharmaceutical bulletin, Vol. 37, Issue 7, pp. 1090-5, (2014) (PubMed).

    Hiasa, Togawa, Miyaji, Omote, Yamamoto, Moriyama: "Essential role of vesicular nucleotide transporter in vesicular storage and release of nucleotides in platelets." in: Physiological reports, Vol. 2, Issue 6, (2014) (PubMed).

  • 抗原
    LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
    别名
    LAMP1 (LAMP1 产品)
    别名
    CD107a antibody, LAMPA antibody, LGP120 antibody, AI196048 antibody, Lamp-1 antibody, LEP100 antibody, LAMP-1 antibody, LGP-A antibody, Lgpa antibody, Lysosome-associated membrane protein 1 antibody, cd107a antibody, lamp-1 antibody, lamp1 antibody, lampa antibody, lgp120 antibody, rexp76 antibody, lysosomal associated membrane protein 1 antibody, lysosomal-associated membrane protein 1 antibody, lysosomal-associated membrane protein 1 L homeolog antibody, LAMP1 antibody, Lamp1 antibody, lamp1.L antibody
    背景
    Lysosme associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37 % sequence homology (2). They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane (3). Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxylterminal tyrosine ba based motif (YXXI) (1). If there is a disturbance in this spacing, lysosome localization of LAMP1 is abolished and the mutant protein then cycles between the membrane and the endosome (3). This stimulation has also been shown to have an associated release of histamine, leukotriene C (4) and prostaglandin D (2), which shows that LAMP-1 and LAMP-2 are activation markers for normal mast cells (1). They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation (4).
    基因ID
    25328
    NCBI登录号
    NP_036989
    UniProt
    P14562
    途径
    Autophagy
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