电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

Lysine (lys) (methylated) 抗体 (HRP)

lys WB, ICC, IF, IP, ELISA 宿主: 兔 Polyclonal HRP
产品编号 ABIN361689
发货至: 中国
  • 抗原
    Lysine (lys)
    抗原表位
    • 23
    • 10
    methylated
    适用
    请咨询
    宿主
    • 21
    • 12
    克隆类型
    • 21
    • 12
    多克隆
    标记
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    HRP
    应用范围
    • 33
    • 32
    • 32
    • 32
    • 32
    • 11
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), ELISA
    特异性
    Detects proteins containing methylated lysine residues.
    纯化方法
    Protein A Purified
    免疫原
    Methylated KLH Conjugated
  • 应用备注
    • WB (1:5000)
    • ICC/IF (1:50)
    • optimal dilutions for assays should be determined by the user.
    说明

    0.2-0.5 μg/ml of SPC-160 was sufficient for detection of the methylated histone by western blot analysis using melanoma cells in TBSt.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    PBS, 50 % glycerol, Storage buffer may change when conjugated
    储存条件
    4 °C
    储存方法
    Conjugated antibodies should be stored at 4°C
  • 抗原
    Lysine (lys)
    别名
    Lysine
    别名
    lysine antibody, lys antibody
    物质类
    Amino Acid
    背景
    Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of Lysine involves acetylation (1). The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (2). Protein posttranslational reversible lysine Nε-acetylation and deacetylation have been recognized as an emerging intracellular signaling mechanism that plays critical roles in regulating gene transcription, cell-cycle progression, apoptosis, DNA repair, and cytoskeletal organization (3). The regulation of protein acetylation status is impaired in the pathologies of cancer and polyglutamine diseases (4), and HDACs have become promising targets for anti-cancer drugs currently in development (5).
You are here:
客服