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TRKA 抗体 (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (pTyr791)

Details for Product anti-NTRK1 Antibody No. ABIN358249, 供应商: Log in to see
抗原
  • trk
  • trka
  • TRKA
  • MTC
  • TRK
  • TRK1
  • Trk-A
  • p140-TrkA
  • C80751
  • Tkr
  • TrkA
  • Trk
  • CTRKA
  • trkA
  • CAPM1
  • CFTD
  • NEM1
  • OK/SW-cl.5
  • TM-5
  • TM3
  • TM30
  • TM30nm
  • TM5
  • TPMsk3
  • hscp30
  • neurotrophic tyrosine kinase, receptor, type 1
  • tropomyosin 3
  • ntrk1
  • NTRK1
  • LOC100354292
  • Ntrk1
  • TPM3
Alternatives
anti-人 TRKA 抗体 for Cell Culture
抗原表位
pTyr791
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适用

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宿主

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克隆类型
多克隆
标记
This TRKA antibody is un-conjugated
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应用范围
Enzyme Immunoassay (EIA), Western Blotting (WB)
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Supplier
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免疫原 This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y791 of human TrkA.
亚型 Ig
特异性 This antibody detects TrKA pTyr791.
纯化方法 Protein G Affinity Chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
别名 TrkA (NTRK1 Antibody 摘要)
背景 TrkA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in the TrkA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.Synonyms: High affinity nerve growth factor receptor, NTRK1, Neurotrophic tyrosine kinase receptor type 1, TRK, TRK1-transforming tyrosine kinase protein, Trk-A, p140-TrkA
分子量 87511 Da
基因ID 4914, 9606
UniProt P04629
研究领域 Cancer
途径 RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
应用备注 ELISA: 1/1,000Western Blot: 1/100-1/500. Dot Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
状态 Liquid
浓度 0.25 mg/mL
缓冲液 PBS with 0.09 % (W/V) Sodium Azide as preservative.
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
厂商提供的图像
 image for anti-TRKA 抗体 (Neurotrophic Tyrosine Kinase, Receptor, Type 1) (pTyr791) (ABIN358249) anti-Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (pTyr791) antibody
背景 Tacconelli, Farina, Cappabianca, Desantis, Tessitore, Vetuschi, Sferra, Rucci, Argenti, Screpanti, Gulino, Mackay: "TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma." in: Cancer cell, Vol. 6, Issue 4, pp. 347-60, 2004 (PubMed).

Frattini, Ferrario, Bressan, Balestra, De Cecco, Mondellini, Bongarzone, Collini, Gariboldi, Pilotti, Pierotti, Greco: "Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer." in: Oncogene, Vol. 23, Issue 44, pp. 7436-40, 2004 (PubMed).

Flørenes, Maelandsmo, Holm, Reich, Lazarovici, Davidson: "Expression of activated TrkA protein in melanocytic tumors: relationship to cell proliferation and clinical outcome." in: American journal of clinical pathology, Vol. 122, Issue 3, pp. 412-20, 2004 (PubMed).

Woo, Lucarelli, Thiele: "NGF activation of TrkA decreases N-myc expression via MAPK path leading to a decrease in neuroblastoma cell number." in: Oncogene, Vol. 23, Issue 8, pp. 1522-30, 2004 (PubMed).

Guo, Liao, Soong, Tsai, Niu, Lee, Lin: "Congenital insensitivity to pain with anhidrosis in Taiwan: a morphometric and genetic study." in: European neurology, Vol. 51, Issue 4, pp. 206-14, 2004 (PubMed).