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TLR1 抗体 (C-Term)

TLR1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN357041
发货至: 中国
  • 抗原 See all TLR1 抗体
    TLR1 (Toll-Like Receptor 1 (TLR1))
    抗原表位
    • 16
    • 10
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 73
    • 48
    • 29
    • 4
    • 4
    • 1
    人, 小鼠
    宿主
    • 72
    • 15
    • 2
    克隆类型
    • 75
    • 14
    多克隆
    标记
    • 36
    • 14
    • 10
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TLR1 antibody is un-conjugated
    应用范围
    • 68
    • 37
    • 32
    • 29
    • 14
    • 13
    • 13
    • 9
    • 8
    • 8
    • 6
    • 4
    • 4
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This antibody detects TLR1 at C-term.
    纯化方法
    Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    免疫原
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of Mouse TLR1.
    亚型
    Ig Fraction
    Top Product
    Discover our top product TLR1 Primary Antibody
  • 应用备注
    ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.25 mg/mL
    缓冲液
    PBS with 0.09 % (W/V) Sodium Azide as preservative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • 抗原
    TLR1 (Toll-Like Receptor 1 (TLR1))
    别名
    CD281 / TLR1 (TLR1 产品)
    别名
    CD281 antibody, TIL antibody, TIL. LPRS5 antibody, rsc786 antibody, toll like receptor 1 antibody, toll-like receptor 1 antibody, TLR1 antibody, Tlr1 antibody
    背景
    Higher animals establish host defense by orchestrating innate and adaptive immunity. This is mediated by professional antigen presenting cells, i.e. dendritic cells (DCs). DCs can incorporate pathogens, produce a variety of cytokines, maturate, and present pathogen-derived peptides to T cells, thereby inducing T cell activation and differentiation. These responses are triggered by microbial recognition through type I transmembrane proteins, Toll-like receptors (TLRs) on DCs. TLRs consist of ten members and each TLR is involved in recognizing a variety of microorganism-derived molecular structures. TLR ligands include cell wall components, proteins, nucleic acids, and synthetic chemical compounds, all of which can activate DCs as immune adjuvants. Each TLR can activate DCs in a similar, but distinct manner. For example, TLRs can be divided into subgroups according to their type I interferon (IFN) inducing ability. TLR2 cannot induce IFN-alpha or IFN-beta, but TLR4 can lead to IFN-beta production. Meanwhile, TLR3, TLR7, and TLR9 can induce both IFN-alpha and IFN-beta. Recent evidences suggest that cytoplamic adapters for TLRs are especially crucial for this functional heterogeneity.Synonyms: KIAA0012, TIL, Toll-like receptor 1, Toll/interleukin-1 receptor-like protein
    基因ID
    21897, 10090
    UniProt
    Q9EPQ1
    途径
    TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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