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CACNA1C 抗体 (AA 50-100)

CACNA1C 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN350137
发货至: 中国
  • 抗原 See all CACNA1C 抗体
    CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))
    抗原表位
    • 12
    • 9
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 50-100
    适用
    • 33
    • 21
    • 21
    • 15
    • 1
    • 1
    宿主
    • 28
    • 16
    • 1
    • 1
    • 1
    克隆类型
    • 32
    • 15
    多克隆
    标记
    • 25
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CACNA1C antibody is un-conjugated
    应用范围
    • 30
    • 23
    • 19
    • 17
    • 15
    • 13
    • 11
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    特异性
    Specific for CACNA1C.
    交叉反应
    人, 小鼠, 大鼠
    交叉反应 (详细)
    Other species not yet tested.
    纯化方法
    IgG
    免疫原
    A synthetic peptide from AA 50-100 of human CACNA1C conjugated to blue carrier protein was used as the antigen. The antigen shares 96% identity with mouse, rat and rabbit sequence.
    亚型
    IgG
    Top Product
    Discover our top product CACNA1C Primary Antibody
  • 应用备注
    IHC, WB (confirmed by recombinant protein). A dilution of 1 : 1000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
    注意事项
    Avoid freeze and thaw cycles.
    储存条件
    4 °C/-20 °C
    储存方法
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    有效期
    12 months
  • 抗原
    CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))
    别名
    CACNA1C (CACNA1C 产品)
    别名
    CACH2 antibody, CACN2 antibody, CACNL1A1 antibody, CCHL1A1 antibody, CaV1.2 antibody, LQT8 antibody, TS antibody, Cav1.2 antibody, Cchl1a1 antibody, MBC antibody, MELC-CC antibody, RATIVS302 antibody, isl antibody, C-LTCC antibody, CHCACHA1C antibody, ICA antibody, cav1.2 antibody, ca(v)1.2 antibody, CAV1.2 antibody, BCR antibody, rbc antibody, calcium voltage-gated channel subunit alpha1 C antibody, calcium channel, voltage-dependent, L type, alpha 1C subunit antibody, voltage-dependent L-type calcium channel subunit alpha-1C antibody, calcium channel, voltage-dependent, L type, alpha 1C subunit S homeolog antibody, Red blood cell count antibody, RNA, 7SL, cytoplasmic 263, pseudogene antibody, CACNA1C antibody, Cacna1c antibody, cacna1c antibody, LOC100442085 antibody, cacna1c.S antibody, RBC antibody, RN7SL263P antibody
    背景
    Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Subcellular location: Membrane, Multi-pass membrane protein. Tissue specificity: Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle.,Alpha Subunit,CACH2, CACN2, CACNL1A1, CCHL1A1, Voltage-gated calcium channel subunit alpha Cav1.2, Calcium channel, L type, alpha-1 polypeptide, cardiac muscle, Voltage dependent L-type calcium channel subunit alpha-1C
    UniProt
    Q13936
    途径
    Hormone Transport, Carbohydrate Homeostasis
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