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ASIC1 抗体 (AA 480-528)

ACCN2 适用: 小鼠, 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN350045
发货至: 中国
  • 抗原 See all ASIC1 (ACCN2) 抗体
    ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))
    抗原表位
    • 15
    • 14
    • 13
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 480-528
    适用
    • 75
    • 68
    • 41
    • 12
    • 11
    • 6
    • 6
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    小鼠, 人, 大鼠
    宿主
    • 74
    • 16
    • 1
    • 1
    • 1
    克隆类型
    • 77
    • 16
    多克隆
    标记
    • 30
    • 6
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ASIC1 antibody is un-conjugated
    应用范围
    • 88
    • 36
    • 26
    • 17
    • 17
    • 14
    • 13
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    特异性
    Specific for AISC1.
    免疫原
    A synthetic peptide from aa region 480-528 of human ASIC1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
    亚型
    IgG
    Top Product
    Discover our top product ACCN2 Primary Antibody
  • 应用备注
    A concentration of 10-50 µg/ml is recommended.
    The optimal dilution should be determined by the end user.
    Not yet tested in other applications.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
    注意事项
    Avoid freeze and thaw cycles.
    储存条件
    4 °C/-20 °C
    储存方法
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    有效期
    12 months
  • 抗原
    ASIC1 (ACCN2) (Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2))
    别名
    ASIC1 (ACCN2 产品)
    别名
    ACCN2 antibody, ASIC antibody, BNaC2 antibody, Accn2 antibody, ASIC1 antibody, AI843610 antibody, ASIC1a antibody, B530003N02Rik antibody, acid sensing ion channel subunit 1 antibody, acid-sensing (proton-gated) ion channel 1 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 antibody, ASIC1 antibody, Asic1 antibody, asic1 antibody, SMARCD1 antibody
    背景
    This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobictransmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit, however, its function as an ion channel remains unknown.
    Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+).
    Subcellular location: Cell membrane, Multi-pass membrane protein. Note: Localizes in synaptosomes at dendritic synapses of neurons.
    Tissue specificity: Expressed in dorsal root ganglia (DRG) and sciatic nerve (at protein level). Widely distributed throughout the brain. Expressed inolfactory bulb, neo and allocortical regions, dentate granule cells, pyramidal cells of CA1-CA3 subfields of the hippocampal formation, habenula, basolateral amygdaloid nuclei, and in the Purkinje and granule cells of the cerebellum. Diffusely detected over most other regions of the basal ganglia, including thalamic nuclei, substantia nigra, striatum and globus pallidus, hypothalamus, midbrain, pons, medulla and choroid plexus. Isoform 3 is expressed only in dorsal root ganglion  while isoform 1 is expressed in DRG, spinal chord, trigeminal ganglia and the trigeminal mesencephalic nucleus. Also known as: Acid-sensing ion channel 1, ASIC1, Brain sodium channel 2, BNaC2, ACCN2.
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