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LBP 抗体

LBP 适用: 人 ELISA, Func 宿主: 小鼠 Monoclonal biG 412 unconjugated
产品编号 ABIN343177
发货至: 中国
  • 抗原 See all LBP 抗体
    LBP (Lipopolysaccharide Binding Protein (LBP))
    适用
    • 38
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    • 9
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    宿主
    • 45
    • 18
    • 5
    • 2
    小鼠
    克隆类型
    • 47
    • 23
    单克隆
    标记
    • 56
    • 7
    • 3
    • 3
    • 1
    This LBP antibody is un-conjugated
    应用范围
    • 47
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    • 9
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    • 5
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    ELISA, Functional Studies (Func)
    纯化方法
    Protein G purified
    免疫原
    LBP knock out mouse immunized with immunoaffinity purified recombinant human LBP
    克隆位点
    BiG 412
    亚型
    IgG1
    Top Product
    Discover our top product LBP Primary Antibody
  • 应用备注
    inhibition of LPS binding to membrane bound CD14, inhibition titre 1:1000. Binding titre at human LBP- ELISA: 1:50.000, cross reacting with bovine LBP.
    限制
    仅限研究用
  • 状态
    Lyophilized
    浓度
    2.0 mg/ml (determined by mouse IgG-ELISA) before lyophilization
    缓冲液
    with NaN3
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • Muansson, Kjaell, Pellett, Nagy, Welch, Baeckhed, Frisan, Richter-Dahlfors: "Role of the lipopolysaccharide-CD14 complex for the activity of hemolysin from uropathogenic Escherichia coli." in: Infection and immunity, Vol. 75, Issue 2, pp. 997-1004, (2007) (PubMed).

    Kato, Ogasawara, Homma, Saito, Matsumoto: "Lipopolysaccharide-binding protein critically regulates lipopolysaccharide-induced IFN-beta signaling pathway in human monocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 10, pp. 6185-94, (2004) (PubMed).

    Berner, Fürll, Stelter, Dröse, Müller, Schütt: "Elevated levels of lipopolysaccharide-binding protein and soluble CD14 in plasma in neonatal early-onset sepsis." in: Clinical and diagnostic laboratory immunology, Vol. 9, Issue 2, pp. 440-5, (2002) (PubMed).

    Vidal, Labéta, Schiffrin, Donnet-Hughes: "Soluble CD14 in human breast milk and its role in innate immune responses." in: Acta odontologica Scandinavica, Vol. 59, Issue 5, pp. 330-4, (2001) (PubMed).

  • 抗原
    LBP (Lipopolysaccharide Binding Protein (LBP))
    别名
    Lipopolysaccharide (LPS)-Binding Protein (LBP) (LBP 产品)
    别名
    BPIFD2 antibody, Bpifd2 antibody, Ly88 antibody, LPSBP antibody, LBP antibody, lipopolysaccharide binding protein antibody, lipopolysaccharide-binding protein antibody, LBP antibody, Lbp antibody, LOC100472839 antibody
    背景
    LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to a 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria
    途径
    TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process
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