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CDH6 抗体

CDH6 适用: 人, 大鼠 WB, IHC, IHC (fro), ICC 宿主: 小鼠 Monoclonal 2B6 unconjugated
产品编号 ABIN335402
发货至: 中国
  • 抗原 See all CDH6 抗体
    CDH6 (K-Cadherin (CDH6))
    适用
    • 66
    • 9
    • 8
    • 5
    • 1
    人, 大鼠
    宿主
    • 61
    • 3
    • 2
    小鼠
    克隆类型
    • 62
    • 4
    单克隆
    标记
    • 27
    • 5
    • 5
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This CDH6 antibody is un-conjugated
    应用范围
    • 65
    • 36
    • 35
    • 31
    • 8
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    特异性
    Human and rat.
    纯化方法
    Purified
    免疫原
    2B6 is a mouse monoclonal IgG1 antibody obtained by fusion of SP2/0 mouse myeloma cells with spleen cells from a BABL/c mouse immunized with affinity purified extracellular domain of human cadherin-6-GST fusion protein.
    克隆位点
    2B6
    亚型
    IgG1
    Top Product
    Discover our top product CDH6 Primary Antibody
  • 应用备注
    2B6 recognizes the extracellular domain of cadherin-6. 2B6 is suitable for immunoblotting, immunocytochemistry and immunohistochemistry on frozen sections when using a PBS buffer containing 0.1 mM CaCl 2 and 0.1 mM MgCl 2 . Optimal antibody dilution should be determined by titration, recommended range is 1:25 - 1:50 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:25 - 1:250 for immunoblotting applications.
    限制
    仅限研究用
  • 储存条件
    4 °C
  • Shimazui, Oosterwijk-Wakka, Akaza, Bringuier, Ruijter, Debruyne, Schalken, Oosterwijk: "Alterations in expression of cadherin-6 and E-cadherin during kidney development and in renal cell carcinoma." in: European urology, Vol. 38, Issue 3, pp. 331-8, (2000) (PubMed).

    Shimazui, Oosterwijk, Akaza, Bringuier, Ruijter, van Berkel, Wakka, van Bokhoven, Debruyne, Schalken: "Expression of cadherin-6 as a novel diagnostic tool to predict prognosis of patients with E-cadherin-absent renal cell carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 4, Issue 10, pp. 2419-24, (1998) (PubMed).

  • 抗原
    CDH6 (K-Cadherin (CDH6))
    别名
    K-Cadherin/Cadherin-6 (CDH6 产品)
    别名
    KCAD antibody, K-cadherin antibody, cad6 antibody, cadherin-6 antibody, CAD6 antibody, c-cad6B antibody, cadherin 6 antibody, Cdh6 antibody, CDH6 antibody
    背景
    Cadherins constitute a family of transmembrane glycoproteins involved in Ca 2+ -dependent cell-cell interactions. The members of this family are differentially expressed in various tissues. They function in the maintenance of tissue integrity and morphogenesis. The cadherins generally contain five extracellular repeats, a transmembrane domain and a cytoplasmic tail that binds to the catenin family of cytoskeletal anchoring proteins which also function as signal transducers. The extracellular domains are responsible for the specificity of homophilic interactions between cells expressing the same cadherin. Cadherins are divided into type I and type II subgroups. Type I cadherins include epithelial cadherin (E-cadherin, cadherin-1 or uvomorulin), neural cadherin (N-cadherin or cadherin-2), placental cadherin (P-cadherin or cadherin-3) and retinal cadherin (R-cadherin or cadherin-4). Kidney cadherin (K-cadherin or cadherin-6) and osteoblast cadherin (OB-cadherin or cadherin-11) are type II cadherins. Cadherin-6 is expressed in the proximal tubule epithelium of the kidney from which most renal cell carcinomas are derived.
    途径
    Cell-Cell Junction Organization
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