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CD56 抗体

NCAM1 适用: 人, 斑马鱼 WB, IHC (p), IHC (fro), ICC 宿主: 小鼠 Monoclonal 123C3 unconjugated
产品编号 ABIN335374
发货至: 中国
  • 抗原 See all CD56 (NCAM1) 抗体
    CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))
    适用
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    人, 斑马鱼
    宿主
    • 151
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    小鼠
    克隆类型
    • 168
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    单克隆
    标记
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    This CD56 antibody is un-conjugated
    应用范围
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    特异性
    Human.
    纯化方法
    Purified
    免疫原
    123C3 is a mouse monoclonal IgG1 antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with the a membrane preparation of a small cell lung carcinoma specimen.
    克隆位点
    123C3
    亚型
    IgG1
    Top Product
    Discover our top product NCAM1 Primary Antibody
  • 应用备注
    123C3 was defined as a cluster I antibody during the First International Workshop on Small Cell Lung Cancer (SCLC) Antibodies. 123C3 recognizes an epitope in the NCAM exons 11-13 which is dependent on an intact conformation of the first fibronectin type-III homologous domain encoded by these exons. 123C3 stains NCAM which is present in small cell lung cancer and lung carcinoids. It also reacts with a number of non-small cell lung carcinomas and neuroendocrine and neuronal derived tissues. In addition, 123C3 is internalized after binding to its antigen on SCLC cell lines, making it an excellent reagent for tumor imaging in xenograft models. 123C3 is suitable for immunoblotting, immunocytochemistry and immunohistochemistry on frozen and paraffin-embedded tissues. Optimal antibody dilution should be determined by titration, recommended range is 1:100 - 1:200 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting applications.
    限制
    仅限研究用
  • 储存条件
    4 °C
  • Kwa, Verheijen, Litvinov, Dijkman, Mooi, Van Krieken: "Prognostic factors in resected non-small cell lung cancer: an immunohistochemical study of 39 cases." in: Lung cancer (Amsterdam, Netherlands), Vol. 16, Issue 1, pp. 35-45, (1997) (PubMed).

    Kwa, Verhoeven, Storm, van Zandwijk, Mooi, Hilkens: "Radioimmunotherapy of small-cell lung cancer xenografts using 131I-labelled anti-NCAM monoclonal antibody 123C3." in: Cancer immunology, immunotherapy : CII, Vol. 41, Issue 3, pp. 169-74, (1995) (PubMed).

    Gerardy-Schahn, Eckhardt: "Hot spots of antigenicity in the neural cell adhesion molecule NCAM." in: International journal of cancer. Supplement = Journal international du cancer. Supplement, Vol. 8, pp. 38-42, (1994) (PubMed).

    Kibbelaar, Moolenaar, Michalides, Van Bodegom, Vanderschueren, Wagenaar, Dingemans, Bitter-Suermann, Dalesio, Van Zandwijk: "Neural cell adhesion molecule expression, neuroendocrine differentiation and prognosis in lung carcinoma." in: European journal of cancer (Oxford, England : 1990), Vol. 27, Issue 4, pp. 431-5, (1991) (PubMed).

    Moolenaar, Muller, Schol, Figdor, Bock, Bitter-Suermann, Michalides: "Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell lines H69 and CHP-212." in: Cancer research, Vol. 50, Issue 4, pp. 1102-6, (1990) (PubMed).

    Schol, Mooi, van der Gugten, Wagenaar, Hilgers: "Monoclonal antibody 123C3, identifying small cell carcinoma phenotype in lung tumours, recognizes mainly, but not exclusively, endocrine and neuron-supporting normal tissues." in: International journal of cancer. Supplement = Journal international du cancer. Supplement, Vol. 2, pp. 34-40, (1988) (PubMed).

    Mooi, Wagenaar, Schol, Hilgers: "Monoclonal antibody 123C3 in lung tumour classification. Immunohistology of 358 resected lung tumours." in: Molecular and cellular probes, Vol. 2, Issue 1, pp. 31-7, (1988) (PubMed).

  • 抗原
    CD56 (NCAM1) (Neural Cell Adhesion Molecule 1 (NCAM1))
    别名
    NCAM / CD56 (NCAM1 产品)
    别名
    CD56 antibody, MSK39 antibody, NCAM antibody, fj56g09 antibody, ncam antibody, ncam1 antibody, wu:fj56g09 antibody, NCAM1 antibody, n-cam antibody, E-NCAM antibody, NCAM-1 antibody, Ncam antibody, Cd56 antibody, N-CAM antibody, N-CAM-1 antibody, NCAM-C antibody, NCAMC antibody, N-CAM-1-B antibody, NCAM-1-B antibody, ncam1-a antibody, ncam1-b antibody, neural cell adhesion molecule 1 antibody, neural cell adhesion molecule 1a antibody, neural cell adhesion molecule 1 S homeolog antibody, neural cell adhesion molecule 1 L homeolog antibody, NCAM1 antibody, ncam1a antibody, ncam1 antibody, LOC100085373 antibody, ncam1.S antibody, Ncam1 antibody, ncam1.L antibody
    背景
    NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins.
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