Desmin 抗体
(8 references)-
- 抗原 See all Desmin (DES) 抗体
- Desmin (DES)
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适用
- 人, 小鼠, 大鼠, 小鸡, Hamster, Pig, 犬, 兔, 斑马鱼
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Desmin antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- Human, mouse, rat, rabbit, hamster, canine, chicken and swine.
- 纯化方法
- Purified
- 免疫原
- RD301 is a mouse monoclonal IgG2b antibody derived by fusion of SP2/0-Ag14 mouse myeloma cells with spleen cells from a mouse immunized with a cytoskeletal desmin extract of chicken gizzard.
- 克隆位点
- RD301
- 亚型
- IgG2b
- Top Product
- Discover our top product DES Primary Antibody
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anti-Desmin (DES) (C-Term) antibody
Verified DES 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Desmin (DES) (AA 1-304) antibodyDES 适用: 人, 小鼠, 大鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Desmin (DES) (AA 261-360) antibodyDES 适用: 人, 小鼠, 大鼠, 小鸡 WB, ELISA, IHC (p), FACS, IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Desmin (DES) antibodyDES 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Desmin (DES) antibodyDES 适用: 人 WB, IHC (p), IF, FACS, IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmin (DES) (AA 121-470) antibodyDES 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Desmin (DES) antibodyDES 适用: 人, 小鼠, 大鼠 IHC (p), IF 宿主: 小鼠 Monoclonal 7A6 unconjugated
anti-Desmin (DES) antibodyDES 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 小鼠 Monoclonal 3E1G4 unconjugated
anti-Desmin (DES) (C-Term) antibodyDES 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Desmin (DES) (AA 361-470) antibodyDES 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D12 unconjugated
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- 应用备注
- RD301 reacts exclusively with desmin, which is expressed in smooth and striated muscle cells and their tumors e.g. rhabdomyosarcoma and leiomyosarcoma. RD301 is suitable for immunoblotting and immunohistochemistry on frozen tissues. Optimal antibody dilution should be determined by titration, recommended range is 1:100 - 1:200 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:1000 for immunoblotting applications.
- 限制
- 仅限研究用
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- 储存条件
- 4 °C
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: "Differential expression of immunohistochemical markers in bladder smooth muscle and myofibroblasts, and the potential utility of desmin, smoothelin, and vimentin in staging of bladder carcinoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 22, Issue 5, pp. 639-50, (2009) (PubMed).
: "Adult rabbit cardiomyocytes undergo hibernation-like dedifferentiation when co-cultured with cardiac fibroblasts." in: Cardiovascular research, Vol. 51, Issue 2, pp. 230-40, (2001) (PubMed).
: "Baby hamster kidney (BHK-21/C13) cells can express striated muscle type proteins." in: Differentiation; research in biological diversity, Vol. 46, Issue 2, pp. 105-15, (1991) (PubMed).
: "Assembly of amino-terminally deleted desmin in vimentin-free cells." in: The Journal of cell biology, Vol. 111, Issue 5 Pt 1, pp. 1971-85, (1990) (PubMed).
: "Desmin and titin expression in early postimplantation mouse embryos." in: Development (Cambridge, England), Vol. 107, Issue 3, pp. 585-96, (1990) (PubMed).
: "Transgenic expression of the muscle-specific intermediate filament protein desmin in nonmuscle cells." in: The Journal of cell biology, Vol. 108, Issue 3, pp. 1009-24, (1989) (PubMed).
: "Differential expression of keratins in the basal and luminal compartments of rat prostatic epithelium during degeneration and regeneration." in: The Prostate, Vol. 13, Issue 1, pp. 25-38, (1988) (PubMed).
: "Characterization of the hamster desmin gene: expression and formation of desmin filaments in nonmuscle cells after gene transfer." in: Cell, Vol. 43, Issue 1, pp. 327-38, (1986) (PubMed).
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: "Differential expression of immunohistochemical markers in bladder smooth muscle and myofibroblasts, and the potential utility of desmin, smoothelin, and vimentin in staging of bladder carcinoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 22, Issue 5, pp. 639-50, (2009) (PubMed).
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- 抗原
- Desmin (DES)
- 别名
- Desmin (DES 产品)
- 背景
- Desmin is a 53 kDa intermediate filament protein that exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development of, for example, skeletal muscle cell differentiation. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogenous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i.e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.
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