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ITGA6 抗体

ITGA6 适用: 人 WB, IHC, IHC (fro), ICC 宿主: 小鼠 Monoclonal 6B4 unconjugated
产品编号 ABIN335350
发货至: 中国
  • 抗原 See all ITGA6 抗体
    ITGA6 (Integrin, alpha 6 (ITGA6))
    适用
    • 118
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    宿主
    • 71
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    小鼠
    克隆类型
    • 66
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    单克隆
    标记
    • 69
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    This ITGA6 antibody is un-conjugated
    应用范围
    • 79
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    特异性
    Human. A broad species reactivity is expected because of the conserved nature of the epitope.
    纯化方法
    Purified
    免疫原
    6B4 is a mouse monoclonal IgG1, kappa antibody derived by fusion of SP2/0 mouse myeloma cells with spleen cells from a BALB/c mouse immunized with a synthetic peptide corresponding to a 34 amino acid stretch in the cytoplasmic domain of integrin alpha6B including an appending N-terminal cysteine: CSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKK coupled to keyhole limpet hemocyanin.
    克隆位点
    6B4
    亚型
    IgG1
    Top Product
    Discover our top product ITGA6 Primary Antibody
  • 应用备注
    6B4 recognizes specifically the cytoplasmic domain of integrin subunit alpha6B. 6B4 stains the basement membrane zone of ducts and acini of salivary gland, kidney tubules, epithelium of colonic crypts and weakly stains sweat glands and sebaceous glands. 6B4 is suitable for immunoblotting, immunocytochemistry and immunohistochemistry on frozen tissues. Optimal antibody dilution should be determined by titration, recommended range is 1:50 - 1:100 for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent, and 1:100 - 1:500 for immunoblotting applications.
    限制
    仅限研究用
  • 缓冲液
    antibody in PBS containing 0.09% Sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
  • Hogervorst, Admiraal, Niessen, Kuikman, Janssen, Daams, Sonnenberg: "Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit." in: The Journal of cell biology, Vol. 121, Issue 1, pp. 179-91, (1993) (PubMed).

  • 抗原
    ITGA6 (Integrin, alpha 6 (ITGA6))
    别名
    Integrin alpha 6B (ITGA6 产品)
    别名
    CD49f antibody, ITGA6B antibody, VLA-6 antibody, 5033401O05Rik antibody, AI115430 antibody, Cd49f antibody, ITGA6 antibody, inta6 antibody, im:6897425 antibody, itga6 antibody, si:dkey-32o22.1 antibody, wu:fb80g02 antibody, LOC100221694 antibody, si:dkey-18j14.1 antibody, wu:fl20e08 antibody, zgc:113088 antibody, integrin subunit alpha 6 antibody, integrin alpha 6 antibody, integrin subunit alpha 6 L homeolog antibody, integrin, alpha 6a antibody, integrin, alpha 6b antibody, ITGA6 antibody, Itga6 antibody, itga6.L antibody, itga6a antibody, itga6b antibody
    背景
    Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. For integrin subunits alpha3 and alpha6, two cytoplasmic variants, A and B, have been identified.
    途径
    CXCR4-mediated Signaling Events, Brown Fat Cell Differentiation, Integrin Complex
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