电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

CBL 抗体 (pTyr700)

CBL 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN319293
发货至: 中国
  • 抗原 See all CBL 抗体
    CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
    抗原表位
    • 28
    • 28
    • 26
    • 17
    • 9
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr700
    适用
    • 171
    • 77
    • 65
    • 2
    • 2
    • 1
    • 1
    宿主
    • 151
    • 18
    • 3
    • 1
    克隆类型
    • 142
    • 31
    多克隆
    标记
    • 76
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    This CBL antibody is un-conjugated
    应用范围
    • 82
    • 52
    • 52
    • 49
    • 32
    • 25
    • 21
    • 16
    • 12
    • 10
    • 9
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    This Antibody detects endogenous levels of c-Cbl only when phosphorylated at Tyrosine 770.
    纯化方法
    Affinity Chromatography
    免疫原
    Synthetic phosphopeptide derived from human c-Cbl around the phosphorylation site of Tyrosine 770 (T-E-YP-M-T).
    Top Product
    Discover our top product CBL Primary Antibody
  • 应用备注
    Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody (in aliquots) at-20 °C.
  • 抗原
    CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
    别名
    CBL / RNF55 (CBL 产品)
    别名
    4732447J05Rik antibody, Cbl-2 antibody, c-Cbl antibody, cbl antibody, C-CBL antibody, CBL2 antibody, FRA11B antibody, NSLL antibody, RNF55 antibody, c-cbl-like antibody, RGD1561386 antibody, Casitas B-lineage lymphoma antibody, Cbl proto-oncogene antibody, Cbl antibody, CBL antibody
    背景
    The proto-oncogene c-CBL was initially identified as the cellular homologue of v-CBL oncogene that induces pre-B cell lymphomas and myeloid leukemias in mice. In more recent studies CBL has been shown to be a negative regulator of tyrosine kinase signaling. The ubiquitin ligase activity of CBL leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors. Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap-70 families. An additional mechanism to attenuate receptor signaling is thought to be achieved by CBL's interaction with downstream targets of tyrosine kinases, such as PI-3K and Vav.Synonyms: CBL2, Casitas B-lineage lymphoma proto-oncogene, E3 ubiquitin-protein ligase CBL, Proto-oncogene c-CBL, RING finger protein 55, Signal transduction protein CBL, c-CBL
    基因ID
    867
    NCBI登录号
    NP_005179
    UniProt
    P22681
    途径
    TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals
You are here:
客服