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KIT 抗体 (pTyr936)

KIT 适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN319287
发货至: 中国
  • 抗原 See all KIT 抗体
    KIT (Mast/stem Cell Growth Factor Receptor (KIT))
    抗原表位
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    pTyr936
    适用
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    宿主
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    克隆类型
    • 594
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    多克隆
    标记
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    This KIT antibody is un-conjugated
    应用范围
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    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    C-kit (phospho-Tyr936) Antibody AP08039PU detects endogenous levels of c-kit only when phosphorylated at Tyrosine 936.
    纯化方法
    Immunoaffinity Chromatography.
    免疫原
    The antiserum was produced against synthesized phosphopeptide derived from human c- kit around the phosphorylation site of Tyrosine 936 (H-I-YP-S-N).
    Top Product
    Discover our top product KIT Primary Antibody
  • 应用备注
    Immunohistochemistry (1/50-1/100).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 缓冲液
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody (in aliquots) at-20 °C.
  • 抗原
    KIT (Mast/stem Cell Growth Factor Receptor (KIT))
    别名
    CD117 / C-Kit (KIT 产品)
    别名
    C-Kit antibody, CD117 antibody, PBT antibody, SCFR antibody, Bs antibody, Fdc antibody, Gsfsco1 antibody, Gsfsco5 antibody, Gsfsow3 antibody, SCO1 antibody, SCO5 antibody, SOW3 antibody, Ssm antibody, Tr-kit antibody, W antibody, c-KIT antibody, c-kit antibody, MGF antibody, KIT antibody, C-KIT antibody, kit antibody, receptor antibody, sparse antibody, Xkl-1 antibody, kit-a antibody, kit-b antibody, kl1-A antibody, krk1 antibody, pbt antibody, scfr antibody, KIT proto-oncogene receptor tyrosine kinase antibody, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a antibody, KIT proto-oncogene receptor tyrosine kinase S homeolog antibody, KIT antibody, Kit antibody, kita antibody, kit antibody, kit.S antibody
    背景
    C-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.Synonyms: KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase, SCFR
    基因ID
    3815
    NCBI登录号
    NP_000213
    UniProt
    P10721
    途径
    RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
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