Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
特异性
This antibody recognises Carabin, also known as TBC1 domain family member 10C (TBC1D10C), a 50 kDa protein belonging to the TBC1 domain family of proteins. This antibody does not cross react with either TBC1D10A or TBC1D10B.
纯化方法
Purified
免疫原
A 17 amino acid peptide from near the amino terminus of human Carabin.
Western Blot: 1 - 2g/mL, detects a band of approximately 55 kDa in human spleen tissuecell lysates. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
CARABIN antibody, EPI64C antibody, 1810062O14Rik antibody, AI428527 antibody, RGD1311490 antibody, TBC1 domain family member 10C antibody, TBC1 domain family, member 10c antibody, TBC1 domain family, member 10C antibody, TBC1D10C antibody, Tbc1d10c antibody
背景
Carabin differs from other members of the TBC1 domain protein family, which appear to play a role in the regulation of cell growth and differentiation. Studies demonstrate that Carabin is part of a negative regulatory loop for the intracellular TCR signalling pathway and acts as an inhibitor of the Ras signalling pathway. Carabin is also believed to mediate crosstalk between calcineurin and Ras. Carabin is most abundantly expressed in spleen and peripheral blood leucocytes.Synonyms: TBC1 domain family member 10C, TBC1D10C