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JNK 抗体 (N-Term)

MAPK8 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3043004
发货至: 中国
  • 抗原 See all JNK (MAPK8) 抗体
    JNK (MAPK8) (Mitogen-Activated Protein Kinase 8 (MAPK8))
    抗原表位
    • 57
    • 28
    • 17
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    • 10
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    AA 1-15, N-Term
    适用
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    宿主
    • 195
    • 18
    • 3
    克隆类型
    • 179
    • 37
    多克隆
    标记
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    This JNK antibody is un-conjugated
    应用范围
    • 163
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    Western Blotting (WB)
    原理
    Rabbit IgG polyclonal antibody for Mitogen-activated protein kinase 8(MAPK8) detection. Tested with WB in Human,Mouse,Rat.
    序列
    MSRSKRDNNF YSVEI
    交叉反应 (详细)
    Predicted Cross Reactivity: mouse, rat
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    产品特性
    Rabbit IgG polyclonal antibody for Mitogen-activated protein kinase 8(MAPK8) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: mitogen-activated protein kinase 8
    Protein Name: Mitogen-activated protein kinase 8
    纯化方法
    Immunogen affinity purified.
    免疫原
    A synthetic peptide corresponding to a sequence at the N-terminus of human JNK1(1-15aa MSRSKRDNNFYSVEI), identical to the related rat and mouse sequences.
    亚型
    IgG
    Top Product
    Discover our top product MAPK8 Primary Antibody
  • 应用备注
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat, The detection limit for MAPK8 is approximately 0.5 ng/lane under reducing conditions.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    储存液
    Thimerosal (Merthiolate), Sodium azide
    注意事项
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    有效期
    12 months
  • Shangguan, Jiang, Pan, Xiao, Tan, Tie, Qin, Deng, Chen, Wang: "Glucocorticoid mediates prenatal caffeine exposure-induced endochondral ossification retardation and its molecular mechanism in female fetal rats." in: Cell death & disease, Vol. 8, Issue 10, pp. e3157, (2018) (PubMed).

    Wang, Gao, Wu, Wang, Song, Chen, Zhang, Zhang, Zhang, Yu: "Pseudolaric acid B induced autophagy, but not apoptosis, in MRC5 human fibroblast cells." in: Oncology letters, Vol. 15, Issue 1, pp. 863-870, (2018) (PubMed).

    Liu, Lv, Ning, Yang, Zhu: "Therapeutic effects of 1,25-dihydroxyvitamin D3 on diabetes-induced liver complications in a rat model." in: Experimental and therapeutic medicine, Vol. 11, Issue 6, pp. 2284-2292, (2016) (PubMed).

    Bu, Zhao, Zhang, Wang, Li, Yan: "Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in gastric carcinoma cells by inducing ER stress." in: American journal of cancer research, Vol. 6, Issue 5, pp. 924-36, (2016) (PubMed).

    Zheng, Liu, Liu, Ma, Zhou, Chen, Chang, Wang, Yang, He: "Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH?SY5Y human neuroblastoma cells." in: Molecular medicine reports, Vol. 10, Issue 1, pp. 89-94, (2014) (PubMed).

    Ding, Zou, Li, Tian, Abdelalim, Du, She, Wang, Tan, Wang, Chen, Lv, Chang: "Study of histopathological and molecular changes of rat kidney under simulated weightlessness and resistance training protective effect." in: PLoS ONE, Vol. 6, Issue 5, pp. e20008, (2011) (PubMed).

    Tian, Qiu, Zhao, Li, Guo: "Sphingomyelinase-induced ceramide production stimulate calcium-independent JNK and PP2A activation following cerebral ischemia." in: Brain injury, Vol. 23, Issue 13-14, pp. 1073-80, (2009) (PubMed).

  • 抗原
    JNK (MAPK8) (Mitogen-Activated Protein Kinase 8 (MAPK8))
    别名
    MAPK8 (MAPK8 产品)
    别名
    JNK antibody, JNK-46 antibody, JNK1 antibody, JNK1A2 antibody, JNK21B1/2 antibody, PRKM8 antibody, SAPK1 antibody, SAPK1c antibody, AI849689 antibody, Prkm8 antibody, BSK antibody, BSK/DJNK antibody, Bsk antibody, CG5680 antibody, D-JNK antibody, D-junk antibody, DBSK/JNK antibody, DJNK antibody, DJNK/bsk antibody, Dmel\\CG5680 antibody, JNK/SAPK antibody, Jnk antibody, Junk antibody, SAPKa antibody, c-Jun antibody, dJNK antibody, jnk antibody, T10F20.15 antibody, jnk1 antibody, sapk1 antibody, mapk8 antibody, zgc:112379 antibody, JNKb antibody, mapk8b antibody, mitogen-activated protein kinase 8 antibody, Stress-activated protein kinase jnk-1 antibody, basket antibody, Protein kinase superfamily protein antibody, mitogen-activated protein kinase 8 L homeolog antibody, mitogen-activated protein kinase 8b antibody, mitogen-activated protein kinase 8B-like antibody, MAPK8 antibody, jnk-1 antibody, Mapk8 antibody, bsk antibody, ATMPK8 antibody, mapk8.L antibody, mapk8b antibody, LOC109094263 antibody
    背景
    MAPK8(Mitogen-activated protein kinase 8), also known as JNK1, PRKM8, and SAPK1, is an enzyme that in humans is encoded by the MAPK8 gene. The protein encoded by this gene is a member of the MAP kinase and JNK family. The International Radiation Hybrid Mapping Consortium mapped the MAPK8 gene to chromosome 10. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. This kinase is also involved in UV radiation-induced apoptosis, which is though to be related to the cytochrome c-mediated cell death pathway.

    Synonyms: AI849689 antibody|c Jun N terminal kinase 1 antibody|C-JUN kinase 1 antibody|c-Jun N-terminal kinase 1 antibody|EC 2.7.11.24 antibody|JAK 1A antibody|JAK1A antibody|JNK 1 antibody|JNK 46 antibody|JNK antibody|JNK-46 antibody|JNK1A2 antibody|JNK21B1/2 antibody|MAP kinase 8 antibody|MAPK 8 antibody|MAPK8 antibody|Mitogen activated protein kinase 8 antibody|Mitogen-activated protein kinase 8 antibody|MK08_HUMAN antibody|p54 gamma antibody|PRKM 8 antibody|PRKM8 antibody|Protein kinase JNK1 antibody|Protein kinase, mitogen-activated, 8 antibody|SAPK 1 antibody|SAPK gamma antibody|SAPK1 antibody|Stress activated protein kinase JNK1 antibody|Stress-activated protein kinase 1 antibody|Stress-activated protein kinase JNK1 antibody|Tyrosine protein kinase JAK1 antibody
    UniProt
    P45983
    途径
    MAPK Pathway, WNT signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, S100 Proteins
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