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Malignant T Cell Amplified Sequence 1 (MCTS1) 抗体

ABIN303009 产品详细信息, 供应商: Log in to see
抗原
  • mcts1
  • MCT-1
  • MGC89874
  • MCTS1
  • MCT1
  • 1500019M23Rik
  • zgc:56242
  • MCT-1A
  • mct-1
  • mct1
  • HHF7
  • MCT
  • RATMCT1
  • RNMCT1
  • AL022710
  • Mct1
  • MCT1a
  • cb517
  • zgc:55682
  • modifier of curly tail 1
  • malignant T cell amplified sequence 1
  • monocarboxylate transporter 1
  • solute carrier family 16 (monocarboxylate transporter), member 1
  • solute carrier family 16 (monocarboxylic acid transporters), member 1
  • solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
  • mct1
  • TEgg094c21.2
  • MCTS1
  • mcts1
  • Mcts1
  • mcts1-a
  • MCT1
  • SLC16A1
  • Slc16a1
  • slc16a1
适用

79
35
24
6
6
5
5
4
3
3
2
2
1
1
1
宿主

54
18
12
克隆类型
多克隆
标记
非结合性
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
应用范围
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
61
25
13
13
12
7
1
1
Supplier
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免疫原 Synthetic peptide
亚型 IgG
特异性 This antibody residues 3-14[KKFDEKENVSNC] of the 20 kDa MCT-1 protein.
纯化方法 Immunoaffinity Chromatography
别名 MCTS1 (MCTS1 Antibody 摘要)
背景 Malignant T cell amplified sequence 1 (MCTS1) is an anti-oncogene that plays a role in cell cycle regulation, decreases cell doubling time and anchorage-dependent growth, shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, MCTS1 increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. MCTS1 plays a role as translation enhancer, and recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile, MCTS1 up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. MCTS1 hyperactivates DNA damage signaling pathway, increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. MCTS1 increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when over-expressed in gamma-irradiated cells. MCTS1 may play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. MCTS1 may contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. MCTS1 is involved in the process of proteosome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell, MCTS1 positively regulates phosphorylation of MAPK1 and MAPK3.Synonyms: MCT-1, MCT1, MCTS1, Malignant T cell amplified sequence 1
基因ID 28985
NCBI登录号 NP_001131026
UniProt Q9ULC4
研究领域 Transporters
应用备注 Immunohistochemistry on paraffin sections: 20 μg/mL. Western Blot: 1: 500 - 1: 1000. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
缓冲液 PBS containing 0.02 % sodium azide
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freezing and thawing.
储存条件 4 °C/-20 °C
储存方法 Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
厂商提供的图像
 image for anti-Malignant T Cell Amplified Sequence 1 (MCTS1) 抗体 (ABIN303009) anti-Malignant T Cell Amplified Sequence 1 (MCTS1) antibody