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CD11c 抗体

ITGAX 适用: 人, 猴 FACS, IP, IHC (fro) 宿主: 小鼠 Monoclonal BU15 unconjugated
产品编号 ABIN302095
发货至: 中国
  • 抗原 See all CD11c (ITGAX) 抗体
    CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))
    适用
    • 163
    • 55
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    • 10
    • 9
    • 9
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    人, 猴
    宿主
    • 114
    • 52
    • 18
    • 14
    • 5
    小鼠
    克隆类型
    • 154
    • 44
    • 2
    单克隆
    标记
    • 75
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    This CD11c antibody is un-conjugated
    应用范围
    • 123
    • 49
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    • 18
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    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    The antibody BU15 reacts with an extracellular epitope of CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages.
    交叉反应 (详细)
    Human, Monkey
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Dendritic cells of synovial fluid
    克隆位点
    BU15
    亚型
    IgG1
    Top Product
    Discover our top product ITGAX Primary Antibody
  • 应用备注
    Flow cytometry: Recommended dilution: 1-4 μg/mL.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • Angel, Lala, Chen, Edgar, Ostrovsky, Dunbar: "CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts." in: International immunology, Vol. 19, Issue 11, pp. 1271-9, (2007) (PubMed).

    Myou, Zhu, Boetticher, Qin, Myo, Meliton, Lambertino, Munoz, Hamann, Leff: "Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2." in: Immunology, Vol. 107, Issue 1, pp. 77-85, (2002) (PubMed).

    Van der Vieren, Le Trong, Wood, Moore, St John, Staunton, Gallatin: "A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3." in: Immunity, Vol. 3, Issue 6, pp. 683-90, (1996) (PubMed).

    Hogg, Takacs, Palmer, Selvendran, Allen: "The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules." in: European journal of immunology, Vol. 16, Issue 3, pp. 240-8, (1986) (PubMed).

  • 抗原
    CD11c (ITGAX) (Integrin, alpha X (Complement Component 3 Receptor 4 Subunit) (ITGAX))
    别名
    CD11c (ITGAX 产品)
    别名
    CD11C antibody, SLEB6 antibody, RGD1561123 antibody, AI449405 antibody, Cd11c antibody, Cr4 antibody, N418 antibody, integrin subunit alpha X antibody, integrin alpha X antibody, ITGAX antibody, Itgax antibody
    背景
    Integrin subunit alpha X,CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b.,Integrin alpha X, ITGAX, SLEB6
    基因ID
    3687
    UniProt
    P20702
    途径
    Complement System, Activated T Cell Proliferation, Integrin Complex
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