PDPK1 抗体 (3-phosphoinositide Dependent Protein Kinase-1) (pSer241)

Details for Product anti-PDPK1 Antibody No. ABIN2959862, 供应商: Log in to see
抗原
  • pdpk1
  • MGC82080
  • PDK1
  • PDPK2
  • PRO0461
  • Pdk1
  • si:zfos-979f1.3
  • 1210
  • BG02759
  • CG1201
  • CG1210
  • DSTPK61
  • Dmel\\CG1210
  • Dstpk61
  • PDK
  • PDK-1
  • PDK1/Pk61C
  • PK61C
  • Pk61C
  • Pk61C/PDK1
  • dPDK-1
  • dPDK1
  • dSTPK61
  • pk61c
  • 3'-phosphoinositide-dependent protein kinase 1
  • 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1
  • ATPDK1
  • AtPDK1
  • T32M21.110
  • T32M21_110
  • 3-phosphoinositide dependent protein kinase 1
  • 3-phosphoinositide dependent protein kinase 1 L homeolog
  • 3-phosphoinositide dependent protein kinase-1
  • 3-phosphoinositide-dependent protein kinase 1
  • pyruvate dehydrogenase kinase, isozyme 1
  • pyruvate dehydrogenase kinase 1
  • Phosphoinositide-dependent kinase 1
  • 3'-phosphoinositide-dependent protein kinase 1
  • PDPK1
  • pdpk1.L
  • pdpk1
  • Pdpk1
  • LOC100380750
  • pdk1
  • PDK1
  • Pdk1
  • pdk-1
抗原表位
pSer241
57
35
32
27
27
26
18
17
15
15
15
15
7
7
6
6
6
5
4
4
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
适用
人, 小鼠, 大鼠
462
218
218
19
13
12
11
11
6
5
4
3
2
1
1
1
1
1
1
1
宿主

381
73
16
克隆类型
多克隆
标记
This PDPK1 antibody is un-conjugated
19
17
16
11
11
7
7
7
7
7
7
7
7
7
7
6
5
5
5
4
3
3
3
2
2
1
1
1
1
1
应用范围
Immunohistochemistry (IHC), Western Blotting (WB)
311
158
99
91
67
64
40
31
22
10
7
5
3
2
1
选项
Supplier
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Supplier Product No.
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免疫原 Synthetic phospho-peptide corresponding to amino acid residues surrounding pSer241
亚型 IgG
特异性 Recognizes the PDK1 protein phosphorylated at serine 241
交叉反应 人, 小鼠, 大鼠
纯化方法 Affinity chromatography
别名 PDK1 (PDPK1 Antibody 摘要)
背景 PDK1 (3-phosphoinositide-dependent protein kinase) is activated by the presence of PtdIns(3,4,5)P3 or PtdIns(3,4)P2 (1). PDK1 then activates protein kinase B (PKB) which, in turn, inactivates glycogen synthase kinase-3 (GSK3). Phosphorylation of other proteins by PKB and GSK3 is likely to mediate many of the intracellular actions of insulin. Thus, PDK1 plays a key role in mediating many of the actions of the second messenger(s) PtdIns(3,4, 5)P3 and/or PtdIns(3,4)P2. The human PDK1 is a 556-residue monomeric enzyme comprising of a catalytic domain that is most similar to the PKA, PKB and PKC subfamily of protein kinases. PDK1 activity is dependent on phosphorylation at Ser241. Other known phosphorylation target sites include Ser25, Ser393, Ser 396 and Ser410 (3).
研究领域 Signaling, Cytoskeleton, Microfilaments, Kinases/Phosphatases
途径 PI3K-Akt Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Regulation of Cell Size, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
限制 仅限研究用
缓冲液 PBS ( pH 7.4) 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
储存条件 4 °C,-20 °C
储存方法 Store at 4 °C (add 0.1% NaN3) for several months, and at -20 °C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature.
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