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pADPR 抗体

适用: 所有种类 IHC, ELISA, WB, IP 宿主: 小鼠 Monoclonal 10H unconjugated
产品编号 ABIN2854257
发货至: 中国
  • 抗原
    pADPR
    适用
    所有种类
    宿主
    • 2
    • 1
    小鼠
    克隆类型
    • 2
    • 1
    单克隆
    标记
    • 1
    • 1
    • 1
    非结合性
    应用范围
    Immunohistochemistry (IHC), ELISA, Western Blotting (WB), Immunoprecipitation (IP)
    产品特性
    Recognizes DNA-damage and apoptosis related poly-ADP ribosylated proteins and poly (ADP-ribose) polymer
    纯化方法
    Protein A affinity column
    免疫原
    poly(ADP-ribose)
    克隆位点
    10H
    亚型
    IgG3
  • 应用备注
    WB 5 µg/mL,
    IH 2 µg/mL
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS, pH 7.4, 1 % BSA, 0.05 % sodium ayide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid freeze/thaw cycles.
    储存条件
    -20 °C
    储存方法
    Stable for 1 year from date of shipment when stored at -20 °C or -70 °C. Stable for at least 1 month at 4 °C.
  • Forst, Karlberg, Herzog, Thorsell, Gross, Feijs, Verheugd, Kursula, Nijmeijer, Kremmer, Kleine, Ladurner, Schüler, Lüscher: "Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains." in: Structure (London, England : 1993), Vol. 21, Issue 3, pp. 462-75, (2013) (PubMed).

    Kashima, Idogawa, Mita, Shitashige, Yamada, Ogi, Suzuki, Toyota, Ariga, Sasaki, Tokino: "CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation." in: The Journal of biological chemistry, Vol. 287, Issue 16, pp. 12975-84, (2012) (PubMed).

    Kotova, Jarnik, Tulin: "Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body." in: PLoS genetics, Vol. 5, Issue 2, pp. e1000387, (2009) (PubMed).

    Gagné, Isabelle, Lo, Bourassa, Hendzel, Dawson, Dawson, Poirier: "Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes." in: Nucleic acids research, Vol. 36, Issue 22, pp. 6959-76, (2008) (PubMed).

    Chang, Coughlin, Mitchison: "Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function." in: Nature cell biology, Vol. 7, Issue 11, pp. 1133-9, (2005) (PubMed).

    Zhang, Yang, Jennings: "Attenuation of neointima formation through the inhibition of DNA repair enzyme PARP-1 in balloon-injured rat carotid artery." in: American journal of physiology. Heart and circulatory physiology, Vol. 287, Issue 2, pp. H659-66, (2004) (PubMed).

  • 抗原
    pADPR
    背景
    Synonyms: poly(ADP-ribose)
    Poly(ADP-ribose) or pADPr is a polymer synthesized by a class of enzymes named poly(ADP-ribose) polymerase (PARP). Using NAD+ as substrate, PARP catalyzes the formation of the polymer pADPr, with chain lengths ranging from 2 to 300 residues, containing approximately 2 % branching in the chain. pADPr becomes attached to nuclear proteins, and to PARP itself (automodification).
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