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AF9 抗体 (N-Term)

MLLT3 适用: 人 WB 宿主: 兔 Polyclonal RB6802 unconjugated
产品编号 ABIN2840635
发货至: 中国
  • 抗原 See all AF9 (MLLT3) 抗体
    AF9 (MLLT3) (Protein AF-9 (MLLT3))
    抗原表位
    • 11
    • 8
    • 7
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 39-65, N-Term
    适用
    • 47
    • 9
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    宿主
    • 46
    • 1
    克隆类型
    • 46
    • 1
    多克隆
    标记
    • 30
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This AF9 antibody is un-conjugated
    应用范围
    • 37
    • 20
    • 17
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    预测反应
    M
    纯化方法
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    免疫原
    This MLLT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-65 amino acids from the N-terminal region of human MLLT3.
    克隆位点
    RB6802
    亚型
    Ig Fraction
    Top Product
    Discover our top product MLLT3 Primary Antibody
  • 应用备注
    WB: 1:1000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    有效期
    6 months
  • 抗原
    AF9 (MLLT3) (Protein AF-9 (MLLT3))
    别名
    MLLT3 (MLLT3 产品)
    别名
    fc39c11 antibody, wu:fc39c11 antibody, zgc:110210 antibody, AF9 antibody, YEATS3 antibody, 2210011H10Rik antibody, 2610012I03Rik antibody, 3830408D16Rik antibody, Af9 antibody, D4Ertd321e antibody, Af-9 antibody, MLLT3, super elongation complex subunit antibody, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 antibody, mllt3 antibody, MLLT3 antibody, Mllt3 antibody
    背景
    The human AF9 gene is one of the most common fusion partner genes with the ALL1 gene at 11q23 (also called MLL), resulting in the t(9,11)(p22,q23). The AF9 gene is more than 100 kb, and 2 patient breakpoint cluster regions (BCRs) have been identified, BCR1 is within intron 4, previously called site A, whereas BCR2 or site B spans introns 7 and 8. Several different structural elements have been identified in AF9, including a colocalizing in vivo DNA topo II cleavage site and an in vitro DNase I hypersensitive (DNase 1 HS) site in intron 7 in BCR2. Reversibility experiments demonstrated a religation of the topo II cleavage sites. In addition, 2 scaffold associated regions (SARs) are located centromeric to the topo II and DNase I HS cleavage sites and border breakpoint regions in 2 leukemic cells lines: SAR1 is located in intron 4, whereas SAR2 encompasses parts of exons 5-7. The patient breakpoint regions of AF9 share the same structural elements as the MLL BCR. A DNA breakage and repair model for nonhomologous recombination between MLL and its partner genes, particularly AF9, has been proposed.
    分子量
    63351
    基因ID
    4300
    NCBI登录号
    NP_004520
    UniProt
    P42568
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