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ATP6V1C1 抗体 (N-Term)

ATP6V1C1 适用: 人, 大鼠, 小鼠, Cow, 犬, 马, 兔, 豚鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2787751
发货至: 中国
  • 抗原 See all ATP6V1C1 抗体
    ATP6V1C1 (ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1))
    抗原表位
    • 4
    • 2
    • 1
    • 1
    • 1
    N-Term
    适用
    • 17
    • 12
    • 9
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 大鼠, 小鼠, Cow, 犬, 马, 兔, 豚鼠, 斑马鱼
    宿主
    • 19
    • 1
    克隆类型
    • 20
    多克隆
    标记
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ATP6V1C1 antibody is un-conjugated
    应用范围
    • 9
    • 9
    • 3
    • 1
    Western Blotting (WB)
    序列
    ldafvegvvk kvaqymadvl edskdkvqen llangvdlvt yitrfqwdma
    预测反应
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
    产品特性
    This is a rabbit polyclonal antibody against ATP6V1C1. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human ATP6V1C1
    Top Product
    Discover our top product ATP6V1C1 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 382 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Meo-Evoli, Almacellas, Massucci, Gentilella, Ambrosio, Kozma, Thomas, Tauler: "V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy." in: Oncotarget, Vol. 6, Issue 29, pp. 28057-70, (2015) (PubMed).

  • 抗原
    ATP6V1C1 (ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1))
    别名
    ATP6V1C1 (ATP6V1C1 产品)
    别名
    ATP6C antibody, ATP6D antibody, VATC antibody, Vma5 antibody, 1700025B18Rik antibody, U13839 antibody, vatC antibody, ATPase antibody, atp6v1c1 antibody, si:zc215i13.2 antibody, wu:fd12h05 antibody, atp6v1c1l antibody, zgc:92684 antibody, ATPase H+ transporting V1 subunit C1 antibody, ATPase, H+ transporting, lysosomal V1 subunit C1 antibody, ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 antibody, ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 L homeolog antibody, ATPase, H+ transporting, lysosomal, V1 subunit C1a antibody, ATPase, H+ transporting, lysosomal, V1 subunit C1b antibody, ATP6V1C1 antibody, Atp6v1c1 antibody, atp6v1c1 antibody, atp6v1c1.L antibody, atp6v1c1a antibody, atp6v1c1b antibody
    背景
    ATP6V1C1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: ATP6C, ATP6D, FLJ20057, VATC, Vma5
    Protein Interaction Partner: ATP6V1C1, IVNS1ABP, ATG7, DNM1L, TSN, STAT1, SNX2, SNX1, SHMT2, SHMT1, SARS, RDX, PAWR, NASP, IDE, GTF2A1, GSPT1, CTTN, PSMG3, ANP32E, TBC1D15, SNX6, VPS35, VPS29, LUC7L2, VTA1, ARFIP1, GSPT2, UBC, UBAC2, TXNDC17, MRPS35, CISD1, VASP, TYMS, SSR1, SRSF5, A
    Protein Size: 382
    分子量
    42 kDa
    基因ID
    528
    NCBI登录号
    NM_001695, NP_001686
    UniProt
    P21283
    途径
    Transition Metal Ion Homeostasis, Proton Transport
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