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COPA 抗体 (N-Term)

COPA 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠, 兔, 斑马鱼, 山羊, Saccharomyces cerevisiae WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2784677
发货至: 中国
  • 抗原 See all COPA 抗体
    COPA (Coatomer Protein Complex, Subunit alpha (COPA))
    抗原表位
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 9
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠, 兔, 斑马鱼, 山羊, Saccharomyces cerevisiae
    宿主
    • 7
    • 1
    • 1
    克隆类型
    • 8
    • 1
    多克隆
    标记
    • 9
    This COPA antibody is un-conjugated
    应用范围
    • 8
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    序列
    PWILTSLHNG VIQLWDYRMC TLIDKFDEHD GPVRGIDFHK QQPLFVSGGD
    预测反应
    Cow: 100%, Dog: 100%, Goat: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 93%, Zebrafish: 100%
    产品特性
    This is a rabbit polyclonal antibody against COPA. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human COPA
    Top Product
    Discover our top product COPA Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 1224 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Li, Custer, Gilson, Hao, Beattie, Androphy: "α-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth." in: Human molecular genetics, Vol. 24, Issue 25, pp. 7295-307, (2015) (PubMed).

    Ting, Wen, Liu, Hsieh-Li, Li, Lin-Chao: "The spinal muscular atrophy disease protein SMN is linked to the Golgi network." in: PLoS ONE, Vol. 7, Issue 12, pp. e51826, (2013) (PubMed).

  • 抗原
    COPA (Coatomer Protein Complex, Subunit alpha (COPA))
    别名
    COPA (COPA 产品)
    别名
    COPA antibody, DDBDRAFT_0189693 antibody, DDBDRAFT_0233797 antibody, DDB_0189693 antibody, DDB_0233797 antibody, DKFZp469O221 antibody, AU040324 antibody, xenin antibody, HEP-COP antibody, cb281 antibody, fb13c12 antibody, wu:fb13c12 antibody, coatomer protein complex subunit alpha antibody, WD40 repeat-containing protein antibody, Coatomer subunit alpha antibody, coatomer protein complex, subunit alpha antibody, coatomer protein complex subunit alpha L homeolog antibody, COPA antibody, copA antibody, cgd8_860 antibody, Chro.80105 antibody, AFUA_3G08840 antibody, copa antibody, Copa antibody, copa.L antibody
    背景
    In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone.In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.
    Alias Symbols: FLJ26320, HEP-COP
    Protein Interaction Partner: UBC, SUMO2, SMN1, STAU1, NUDCD1, SUMO1, NEDD8, RPA3, RPA2, RPA1, SUZ12, RNF2, COPZ1, DHX38, COPB2, CCT3, TCP1, SEPT2, ARCN1, UBD, VCAM1, ITGA4, COPB1, COPG2, COPG1, COPE, SEPT9, SEC23A, SEC24C, UBXN6, FBXO6, LMAN1, SACM1L, DDX20, TMED10, GEMIN2, COPA, CDK
    Protein Size: 1224
    分子量
    135 kDa
    基因ID
    1314
    NCBI登录号
    NM_004371, NP_004362
    UniProt
    P53621
    途径
    Hormone Activity
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