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CD42b 抗体 (C-Term)

GP1BA 适用: 人, 小鼠, 大鼠, 犬, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2784512
发货至: 中国
  • 抗原 See all CD42b (GP1BA) 抗体
    CD42b (GP1BA) (Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA))
    抗原表位
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 69
    • 14
    • 5
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬, 马, 兔
    宿主
    • 35
    • 34
    • 2
    克隆类型
    • 38
    • 33
    多克隆
    标记
    • 39
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This CD42b antibody is un-conjugated
    应用范围
    • 33
    • 33
    • 20
    • 13
    • 10
    • 8
    • 7
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    序列
    RGSLPTFRSS LFLWVRPNGR VGPLVAGRRP SALSQGRGQD LLSTVSIRYS
    预测反应
    Dog: 77%, Horse: 92%, Human: 100%, Mouse: 86%, Rabbit: 79%, Rat: 86%
    产品特性
    This is a rabbit polyclonal antibody against GP1BA. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the C terminal region of human GP1BA
    Top Product
    Discover our top product GP1BA Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 639 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Cooper, Lloyd, Koch, Lin, Dobbs, Theisen, Zuberbuehler, Bernhardt, Gyorfi, Tenpas, Hying, Mortimer, Lamont, Lehmann, Neeves: "Temperature effects on the activity, shape, and storage of platelets from 13-lined ground squirrels." in: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, Vol. 187, Issue 5-6, pp. 815-825, (2017) (PubMed).

  • 抗原
    CD42b (GP1BA) (Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA))
    别名
    GP1BA (GP1BA 产品)
    别名
    BDPLT1 antibody, BDPLT3 antibody, BSS antibody, CD42B antibody, CD42b-alpha antibody, DBPLT3 antibody, GP1B antibody, GPIbA antibody, VWDP antibody, GP1BA antibody, GPIba antibody, GPIbalpha antibody, glycoprotein Ib platelet alpha subunit antibody, glycoprotein Ib (platelet), alpha polypeptide antibody, glycoprotein 1b, alpha polypeptide antibody, GP1BA antibody, Gp1ba antibody
    背景
    Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. GP1BA is the alpha subunit.Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: BSS, CD42B, CD42b-alpha, GP1B, MGC34595, VWDP, GPIbA, BDPLT1, BDPLT3, DBPLT3
    Protein Interaction Partner: DDIT3, OSGEP, TPST1, FLNB, YWHAZ, FLNA, F12, GP1BA, KNG1, VWF, F2, SELP, GP9, GP5, ITGAM, CTSG,
    Protein Size: 639
    分子量
    68 kDa
    基因ID
    2811
    NCBI登录号
    NM_000173, NP_000164
    UniProt
    A5CKE2
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