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E-cadherin 抗体 (Middle Region)

CDH1 适用: 人, 小鼠, 大鼠, Pig, 犬, 兔, Cow, 马, 斑马鱼 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2784498
发货至: 中国
  • 抗原 See all E-cadherin (CDH1) 抗体
    E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
    抗原表位
    • 17
    • 17
    • 16
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    • 14
    • 8
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    • 1
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    • 1
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    Middle Region
    适用
    • 234
    • 95
    • 82
    • 18
    • 16
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    • 6
    • 4
    • 4
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    • 1
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    人, 小鼠, 大鼠, Pig, 犬, 兔, Cow, 马, 斑马鱼
    宿主
    • 201
    • 72
    • 7
    • 3
    克隆类型
    • 187
    • 95
    • 1
    多克隆
    标记
    • 134
    • 36
    • 29
    • 10
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    • 1
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    • 1
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    • 1
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    • 1
    This E-cadherin antibody is un-conjugated
    应用范围
    • 201
    • 87
    • 86
    • 68
    • 53
    • 49
    • 39
    • 35
    • 29
    • 27
    • 17
    • 16
    • 5
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    • 1
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    序列
    QEITSYTAQE PDTFMEQKIT YRIWRDTANW LEINPDTGAI STRAELDRED
    预测反应
    Cow: 93%, Dog: 79%, Horse: 93%, Human: 100%, Mouse: 79%, Pig: 93%, Rabbit: 93%, Rat: 93%, Zebrafish: 85%
    产品特性
    This is a rabbit polyclonal antibody against CDH1. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the middle region of human CDH1
    Top Product
    Discover our top product CDH1 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 882 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
    别名
    CDH1 (CDH1 产品)
    别名
    Arc-1 antibody, CD324 antibody, CDHE antibody, ECAD antibody, LCAM antibody, UVO antibody, E-cadherin antibody, cdh1 antibody, si:dz180o5.2 antibody, uvo antibody, lcam antibody, E-Cad antibody, XBcad antibody, l-cam antibody, xcdh1 antibody, cdhc-A antibody, xb-cad antibody, XTCAD-1 antibody, c-cadherin antibody, cadherin-1 antibody, uvomorulin antibody, XB-cadherin antibody, arc-1 antibody, cd324 antibody, cdhe antibody, ecad antibody, AA960649 antibody, E-cad antibody, Ecad antibody, L-CAM antibody, Um antibody, cadherin 1 antibody, si:busm1-180o5.2 antibody, cadherin 1, type 1, E-cadherin (epithelial) antibody, cadherin 1, type 1 S homeolog antibody, CDH1 antibody, si:busm1-180o5.2 antibody, cdh1 antibody, Cdh1 antibody, cdh1.S antibody
    背景
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: Arc-1, CD324, CDHE, ECAD, LCAM, UVO
    Protein Interaction Partner: UBC, MDM2, UCHL3, CDC27, PTEN, CTNNB1, PIP5K1C, CTNND1, CBLL1, RNF2, GMNN, LMNA, KRT18, KRT9, KRT8, KRT1, IGHA1, HSPD1, HSP90AA1, HSPA9, HSPA8, HSPA5, GBAS, CTNNA1, CRYAB, CFTR, C1QBP, ACTN4, ACADVL, ANP32B, NIPSNAP1, XRCC5, TGM2, SKP2, SET, RAD17, POLR2E
    Protein Size: 882
    分子量
    80 kDa
    基因ID
    999
    NCBI登录号
    NM_004360, NP_004351
    UniProt
    P12830
    途径
    WNT signaling, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
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