This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. Alias Symbols: HsPK21, NEK2A, NLK1 Protein Interaction Partner: ANAPC4, UBC, NEK2, CEP250, CTNNB1, PPP1CC, VCP, CDH1, CDC20, CHEK1, CSN2, CDC27, MYC, PPP1CA, CCDC85A, SPTBN4, GIT1, EDRF1, TCF25, IMMT, NDC80, IFT140, PDE4DIP, TPM3, MCC, EIF4A2, DCTN1, CHGA, Gm9174, Cdc16, Cdc23, NEK11, MAD1L1, PPP1R2, MAPK1, CLEC4C, Protein Size: 437