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NOX1 抗体 (C-Term)

NOX1 适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 斑马鱼, 兔 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2782754
发货至: 中国
  • 抗原 See all NOX1 抗体
    NOX1 (NADPH Oxidase 1 (NOX1))
    抗原表位
    • 8
    • 7
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 47
    • 8
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 斑马鱼, 兔
    宿主
    • 46
    • 2
    • 1
    克隆类型
    • 48
    • 2
    多克隆
    标记
    • 30
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NOX1 antibody is un-conjugated
    应用范围
    • 35
    • 27
    • 12
    • 8
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    序列
    STIATSHPKS VVGVFLCGPR TLAKSLRKCC HRYSSLDPRK VQFYFNKENF
    预测反应
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%
    产品特性
    This is a rabbit polyclonal antibody against NOX1. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the C terminal region of human NOX1
    Top Product
    Discover our top product NOX1 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 564 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Rayegan, Dehpour, Sharifi: "Studying neuroprotective effect of Atorvastatin as a small molecule drug on high glucose-induced neurotoxicity in undifferentiated PC12 cells: role of NADPH oxidase." in: Metabolic brain disease, Vol. 32, Issue 1, pp. 41-49, (2016) (PubMed).

    Kuwano, Kawahara, Yamamoto, Teshima-Kondo, Tominaga, Masuda, Kishi, Morita, Rokutan: "Interferon-gamma activates transcription of NADPH oxidase 1 gene and upregulates production of superoxide anion by human large intestinal epithelial cells." in: American journal of physiology. Cell physiology, Vol. 290, Issue 2, pp. C433-43, (2006) (PubMed).

  • 抗原
    NOX1 (NADPH Oxidase 1 (NOX1))
    别名
    NOX1 (NOX1 产品)
    别名
    GP91-2 antibody, MOX1 antibody, NOH-1 antibody, NOH1 antibody, NOX1a antibody, NOX1alpha antibody, Nox-1 antibody, Nox1 antibody, NADPH oxidase 1 antibody, NOX1 antibody, Nox1 antibody, nox1 antibody
    背景
    Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. They are unique among ion channels with respect to their extremely high selectivity, marked temperature dependence, and unitary conductance, which is 3 orders of magnitude lower than that of most other ion channels. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox.Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. They are unique among ion channels with respect to their extremely high selectivity, marked temperature dependence, and unitary conductance, which is 3 orders of magnitude lower than that of most other ion channels. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Three splice variants of NOX1 have been identified, NOH-1L, NOH-1S and NOH-1Lv. The NOH-1S currents were reversibly blocked by zinc, a known H+ channel inhibitor. The NOH-1S variant does not contain an electron transport chain and it is thought that H+ conductance is its main physiologic function, whereas NOH-1L may conduct H+ ions as part of its electron transport mechanism.
    Alias Symbols: GP91-2, MOX1, NOH-1, NOH1
    Protein Interaction Partner: NOXA1, CYBA,
    Protein Size: 564
    分子量
    65 kDa
    基因ID
    27035
    NCBI登录号
    NM_007052, NP_008983
    UniProt
    Q9Y5S8
    途径
    Regulation of Systemic Arterial Blood Pressure by Hormones, Proton Transport
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