Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, and Dihydroorotase (CAD) (C-Term) 抗体

ABIN2782487 产品详细信息, 供应商: Log in to see
抗原
  • 38E.19
  • CAD
  • CG1759
  • Cad
  • Dmel\\CG1759
  • S67
  • anon-WO2004063362.83
  • cd
  • Cpad
  • AU018859
  • 2410008J01Rik
  • cb456
  • wu:fc30c12
  • wu:fc33d01
  • wu:fc67g02
  • si:dkey-221h15.3
  • xcad
  • 40kDa
  • 5730477D02Rik
  • CPAN
  • DFF40
  • Didff
  • caudal
  • carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  • DNA fragmentation factor, beta polypeptide (caspase-activated DNase)
  • DNA fragmentation factor, beta subunit
  • cad
  • Cad
  • CAD
  • dffb
  • Dffb
抗原表位
C-Term
15
11
11
9
6
5
5
5
4
4
4
3
3
2
1
1
1
1
1
1
适用
牛, 犬, 豚鼠, 马, 人, 小鼠, 兔, 大鼠, Yeast, 斑马鱼
89
42
13
7
6
5
5
4
3
2
2
2
2
1
1
宿主

93
13
克隆类型
多克隆
标记
非结合性
2
2
2
2
2
2
应用范围
Western Blotting (WB)
72
42
39
36
24
19
5
3
1
1
选项
Supplier
Log in to see
Supplier Product No.
Log in to see
免疫原 The immunogen is a synthetic peptide directed towards the C terminal region of human CAD
Blocking Peptide Blocking peptide for this product available: ABIN974393
序列 ADVVVLRHPQ PGAVELAAKH CRRPVINAGD GVGEHPTQAL LDIFTIREEL
预测反应 Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 92%, Zebrafish: 100%
产品特性 This is a rabbit polyclonal antibody against CAD. It was validated on Western Blot using a cell lysate as a positive control.
纯化方法 Affinity Purified
别名 CAD (CAD Antibody 摘要)
背景 CAD is a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: -
Protein Interaction Partner: UBC, TUBG1, TP53, SUMO2, SPRTN, STAU1, LGR4, SUMO1, NEDD8, WWOX, NEDD4, FBXO6, HDAC6, ILK, CDK2, HDAC11, HTRA2, TP63, NOS2, ITGA4, RUVBL1, XPO1, VARS, TUBB2A, TUBA4A, SMARCC2, SMARCA4, RPS3, PSMD1, PSMC2, RUVBL2, TUBB4B, SHC1, SMAD2, GRB2, CBL, CUL3, FBXO
Protein Size: 2225
分子量 243 kDa
基因ID 790
NCBI登录号 NM_004341, NP_004332
UniProt P27708
研究领域 Chromatin and Nuclear Signaling, Cell Cycle, Apoptosis/Necrosis
途径 Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process
应用备注 Optimal working dilutions should be determined experimentally by the investigator.
说明

Antigen size: 2225 AA

限制 仅限研究用
状态 Liquid
浓度 Lot specific
缓冲液 Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
厂商提供的图像
Western Blotting (WB) image for anti-Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, and Dihydroorotase (CAD) (C-Term) antibody (ABIN2782487) anti-Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, and Dihydroorotase (CAD) (C-Term) antibody
背景 Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

您还需要查找其他产品吗?