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BCL11A 抗体 (N-Term)

BCL11A 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2781048
发货至: 中国
  • 抗原 See all BCL11A 抗体
    BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))
    抗原表位
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    N-Term
    适用
    • 63
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    人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 斑马鱼
    宿主
    • 69
    • 9
    克隆类型
    • 60
    • 18
    多克隆
    标记
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    This BCL11A antibody is un-conjugated
    应用范围
    • 60
    • 24
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    • 13
    • 9
    • 9
    • 5
    • 5
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    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    MSRRKQGKPQ HLSKREFSPE PLEAILTDDE PDHGPLGAPE GDHDLLTCGQ
    预测反应
    Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 100%
    产品特性
    This is a rabbit polyclonal antibody against BCL11A. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human BCL11A
    Top Product
    Discover our top product BCL11A Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 835 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Uda, Galanello, Sanna, Lettre, Sankaran, Chen, Usala, Busonero, Maschio, Albai, Piras, Sestu, Lai, Dei, Mulas, Crisponi, Naitza, Asunis, Deiana, Nagaraja, Perseu, Satta, Cipollina, Sollaino, Moi, Hirschhorn, Orkin, Abecasis, Schlessinger, Cao: "Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 5, pp. 1620-5, (2008) (PubMed).

  • 抗原
    BCL11A (B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))
    别名
    BCL11A (BCL11A 产品)
    别名
    2810047E18Rik antibody, BCL-11A antibody, Ctip1 antibody, D930021L15Rik antibody, Evi9 antibody, Evi9a antibody, Evi9b antibody, Evi9c antibody, mKIAA1809 antibody, BCL11A-L antibody, BCL11A-S antibody, BCL11A-XL antibody, BCL11a-M antibody, CTIP1 antibody, EVI9 antibody, HBFQTL5 antibody, ZNF856 antibody, bcl11a antibody, wu:fi09f10 antibody, zgc:136898 antibody, B cell CLL/lymphoma 11A (zinc finger protein) antibody, B-cell CLL/lymphoma 11A antibody, B-cell CLL/lymphoma 11A L homeolog antibody, B-cell CLL/lymphoma 11Aa antibody, Bcl11a antibody, BCL11A antibody, bcl11a.L antibody, bcl11aa antibody
    背景
    BCL11A Is a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression.This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.
    Alias Symbols: BCL11A-L, BCL11A-S, BCL11A-XL, CTIP1, EVI9, FLJ10173, FLJ34997, HBFQTL5, KIAA1809, ZNF856
    Protein Interaction Partner: GMCL1P1, ZBTB24, NCK2, LMO1, NR2E3, NR2E1, NR2F2, NR2F1, NR2F6, HDAC2, HDAC1, CDCA3, YME1L1, CDK6, CDK4, ACTC1, APP, UBC, BCL6, BCL11A, Sumo1, SUMO2, SUMO3, SIRT1, MBD3, MTA2, MTA1, CHD4,
    Protein Size: 835
    分子量
    91 kDa
    基因ID
    53335
    NCBI登录号
    NM_022893, NP_075044
    UniProt
    Q9H165
    途径
    Regulation of Cell Size
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