MLLT3 is a regulator of early erythroid and megakaryocytic cell fate in the human system. Expression of MLLT3 in human CD34+ cells induces acute myeloid, lymphoid, or mixed-lineage leukemia in immunodeficient mice. Translocation t (9,11)(p22,q23), a chromosomal aberration involving MLLT3 is associated with acute leukemias.
Alias Symbols: AF9, FLJ2035, YEATS3
Protein Interaction Partner: CDK9, HSP90B1, EAF1, AFF4, ELL2, MED26, ELL, MLLT3, AFF1, MLLT1, CDK6, CCNT1, CCNT2, APP, Cbx8, DOT1L, PAF1, KMT2A, BCOR, MLLT10, RNF2, AFF3, EEF2, ACACA, PCGF1, ELL3, NIPBL, SIRT1, LRIF1, RBM48, APPBP2, MCM6, PTN, EEF1A1, SGK1,
Protein Size: 342