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APEX1 抗体 (N-Term)

APEX1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 马, 豚鼠, 山羊 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2779778
发货至: 中国
  • 抗原 See all APEX1 抗体
    APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
    抗原表位
    • 7
    • 7
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 87
    • 37
    • 34
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, Cow, 犬, 兔, 马, 豚鼠, 山羊
    宿主
    • 70
    • 18
    • 2
    克隆类型
    • 72
    • 18
    多克隆
    标记
    • 67
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This APEX1 antibody is un-conjugated
    应用范围
    • 83
    • 30
    • 29
    • 27
    • 20
    • 13
    • 8
    • 7
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    KGLDWVKEEA PDILCLQETK CSENKLPAEL QELPGLSHQY WSAPSDKEGY
    预测反应
    Cow: 92%, Dog: 92%, Goat: 83%, Guinea Pig: 85%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%
    产品特性
    This is a rabbit polyclonal antibody against APEX1. It was validated on Western Blot and immunohistochemistry.
    纯化方法
    Protein A purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human APEX1
    Top Product
    Discover our top product APEX1 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 318 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
    别名
    APEX1 (APEX1 产品)
    别名
    apex1 antibody, MGC76280 antibody, MGC79645 antibody, MGC78928 antibody, APE antibody, APE1 antibody, APEN antibody, APEX antibody, APX antibody, HAP1 antibody, REF1 antibody, Apex antibody, REF-1 antibody, BAP1 antibody, apex1a antibody, hm:zehn1532 antibody, wu:fc13d11 antibody, zgc:66204 antibody, Ref-1 antibody, apurinic/apyrimidinic endodeoxyribonuclease 1 antibody, APEX nuclease (multifunctional DNA repair enzyme) 1 antibody, APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog antibody, DNA-(apurinic or apyrimidinic site) lyase antibody, apurinic/apyrimidinic endonuclease 1 antibody, APEX1 antibody, apex1 antibody, apex1.L antibody, CNG03640 antibody, CNH01280 antibody, nth antibody, Spirs_4119 antibody, Palpr_0103 antibody, Apex1 antibody
    背景
    Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells.
    Alias Symbols: APE, APX, APE1, APEN, APEX, HAP1, REF1
    Protein Interaction Partner: GADD45A, UBC, RPA3, RPA2, RPA1, rev, CCDC124, RIC8A, PABPC1, TWF2, XPOT, HNRNPUL1, ARIH2, PAPSS2, NAE1, PSMG1, TXNRD1, TXN, TCEB1, LGALS1, HNRNPK, CAPNS1, SRPK2, SRPK1, MUTYH, HMGA1, HMGA2, GZMK, GZMA, YBX1, EP300, ASCL2, STAT3, SNRPD1, SFPQ, APP, UBE2I,
    Protein Size: 318
    分子量
    35 kDa
    基因ID
    328
    NCBI登录号
    NM_080648, NP_542379
    UniProt
    P27695
    途径
    DNA Damage Repair, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
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