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SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (Middle Region) 抗体

ABIN2779689 产品详细信息, 供应商: Log in to see
抗原
抗原表位
Middle Region
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适用
牛, 犬, 豚鼠, 马, 人, 小鼠, 猪, 兔, 大鼠
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宿主

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克隆类型
多克隆
应用范围
Chromatin Immunoprecipitation (ChIP), Immunohistochemistry (IHC), Western Blotting (WB)
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Supplier
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免疫原 The immunogen is a synthetic peptide directed towards the middle region of human SUZ12
Blocking Peptide Blocking peptide for this product available: ABIN984652
序列 TGETNDKSTA PIAKPLATRN SESLHQENKP GSVKPTQTIA VKESLTTDLQ
预测反应 Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
产品特性 This is a rabbit polyclonal antibody against SUZ12. It was validated on Western Blot using a cell lysate as a positive control.
纯化方法 Affinity Purified
别名 SUZ12
背景 A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t (7,17)(p15,q21) with JAZF1 generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CHET9, JJAZ1, KIAA0160
Protein Interaction Partner: FBXW11, EZH2, BRCA1, CDK5RAP2, RBM22, LUC7L, NHP2, H2AFY2, C17orf85, NAT10, ATAD3A, HEATR1, PTCD3, CHCHD3, CDKAL1, DDX56, GDAP1, LUC7L3, SF3B6, LUC7L2, NOP58, LIMA1, CDC40, CRNKL1, HP1BP3, STOML2, TRA2A, RBM15B, REPIN1, PRPF19, AKAP8L, TBL2, DAZAP1, PHGDH
Protein Size: 739
分子量 83 kDa
基因ID 23512
NCBI登录号 NM_015355, NP_056170
UniProt Q15022
研究领域 Chromatin and Nuclear Signaling, Transcription Factors
应用备注 Optimal working dilutions should be determined experimentally by the investigator.
说明

Antigen size: 739 AA

限制 仅限研究用
状态 Liquid
浓度 Lot specific
缓冲液 Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
厂商提供的图像
Immunohistochemistry (IHC) image for anti-SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (Middle Region) 抗体 (ABIN2779689) anti-SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (Middle Region) antibody
Chromatin Immunoprecipitation (ChIP) image for anti-SUZ12 Polycomb Repressive Complex 2 Subunit (SUZ12) (Middle Region) 抗体 (ABIN2779689) Chromatin Immunoprecipitation (ChIP) Using SUZ12 Antibody - middle region (ARP32515_P...
背景 Li, Ma, Wang, Koontz, Nucci, Sklar: "Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 50, pp. 20001-6, 2007 (PubMed).