SMAD, Mothers Against DPP Homolog 1 (SMAD1) (Middle Region) 抗体

ABIN2779411 产品详细信息, 供应商: Log in to see
抗原
  • MLP
  • Xmad1
  • Xsmad1
  • bsp1
  • jv4-1
  • jv41
  • madh1
  • madr1
  • smad-1
  • MADH1
  • fb39h09
  • wu:fb39h09
  • wu:fb97e04
  • 2/23
  • CG12399
  • Dmel\\CG12399
  • E(zen)2
  • En(vvl)
  • MAD
  • Mat
  • P-Mad
  • P-mad
  • PMad
  • Smad
  • Smad1
  • apg
  • c28
  • dMAD
  • dMad
  • l(2)K00237
  • l(2)k00237
  • mad
  • p-Mad
  • pMAD
  • pMad
  • pSmad
  • BSP-1
  • BSP1
  • JV4-1
  • JV41
  • MADR1
  • AI528653
  • Madh1
  • Madr1
  • Mlp1
  • MusMLP
  • smad1
  • xmad
  • SMAD family member 1
  • MAD homolog 1 (Drosophila)
  • Mothers against dpp
  • smad1
  • SMAD1
  • Mad
  • Smad1
  • smad1-a
抗原表位
Middle Region
49
34
20
19
19
15
13
8
8
7
5
5
5
4
4
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
适用
牛, 犬, 豚鼠, 马, 人, 小鼠, 兔, 大鼠, 绵羊
314
203
181
15
15
13
12
11
9
8
8
6
6
6
5
3
2
2
2
2
2
2
2
2
1
1
宿主

290
45
2
克隆类型
多克隆
标记
非结合性
11
9
6
3
3
3
3
3
3
3
3
3
3
3
2
2
2
应用范围
Western Blotting (WB)
293
129
70
49
39
39
20
16
7
6
5
4
2
2
1
1
1
1
1
选项
Supplier
Log in to see
Supplier Product No.
Log in to see
免疫原 The immunogen is a synthetic peptide directed towards the middle region of human SMAD1
Blocking Peptide Blocking peptide for this product available: ABIN984093
序列 LAQFRNLGQN EPHMPLNATF PDSFQQPNSH PFPHSPNSSY PNSPGSSSST
特异性 This antibody reacts with SMAD1 + SMAD5.
预测反应 Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%
产品特性 This is a rabbit polyclonal antibody against SMAD1. It was validated on Western Blot using a cell lysate as a positive control.
纯化方法 Affinity Purified
别名 SMAD1 (SMAD1 Antibody 摘要)
背景 SMAD1 belongs to the SMAD family. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD1 mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, SMAD1 can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of SMAD1 forms a complex with SMAD4, which is important for its function in the transcription regulation. SMAD1 is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Alias Symbols: BSP1, JV4-1, JV41, MADH1, MADR1, BSP-1
Protein Interaction Partner: HDAC1, SMURF1, WDR77, AR, UBC, ACVRL1, SMAD4, LEMD3, MAPK1, GSK3B, ZNF521, ZNF423, AKR1B1, AP2A2, PIAS4, ZDHHC3, HBP1, IRF2BP1, SF3B1, MGA, ZNF510, ICK, GMEB1, ZEB2, PUM1, PIGQ, PIAS1, TTF2, KMT2D, ZNF76, XPC, TTF1, SOX5, SNRNP70, SMAD3, SMAD2, SMAD1, INP
Protein Size: 465
分子量 52 kDa
基因ID 4086
NCBI登录号 NM_005900, NP_005891
UniProt Q15797
研究领域 Signaling, Transcription Factors
途径 Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
应用备注 Optimal working dilutions should be determined experimentally by the investigator.
说明

Antigen size: 465 AA

限制 仅限研究用
状态 Liquid
浓度 Lot specific
缓冲液 Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
厂商提供的图像
Western Blotting (WB) image for anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (Middle Region) antibody (ABIN2779411) WB Suggested Anti-SMAD1 Antibody Titration: 0.2-1 ug/ml
Positive Control...
Western Blotting (WB) image for anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (Middle Region) antibody (ABIN2779411) WB Suggested Anti-SMAD1
Antibody Titration: 0.2-1 µg/mL
Positive Contro...
背景 Blount, Vaughan, Vale, Bilezikjian: "A Smad-binding element in intron 1 participates in activin-dependent regulation of the follistatin gene." in: The Journal of biological chemistry, Vol. 283, Issue 11, pp. 7016-26, 2008 (PubMed).

Blount, Merlie: "BIP associates with newly synthesized subunits of the mouse muscle nicotinic receptor." in: The Journal of cell biology, Vol. 113, Issue 5, pp. 1125-32, 1991 (PubMed).

您还需要查找其他产品吗?