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p53 抗体 (Tumor Protein P53) (N-Term)

Details for Product anti-TP53 Antibody No. ABIN2779330, 供应商: Log in to see
抗原
  • tp53
  • p53
  • TP53
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • TpMs
  • BCC7
  • LFS1
  • P53
  • TRP53
  • Trp53
  • Xp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • cellular tumor antigen p53
  • tumor protein p53
  • tumor supressor p53
  • p53 tumor suppressor
  • transformation related protein 53
  • transformation related protein 53, pseudogene
  • trichoplein, keratin filament binding
  • Wistar clone pR53P1 p53 pseudogene
  • CpipJ_CPIJ002758
  • TP53
  • tp53
  • P53
  • Trp53
  • Trp53-ps
  • TCHP
  • Tp53
  • p53-ps
Alternatives
anti-人 p53 抗体 for Affinity Purification
抗原表位
N-Term
170
117
84
83
69
65
55
55
54
53
49
47
46
45
40
32
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31
25
23
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2
2
2
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2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
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1
1
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适用

2329
514
419
186
127
94
85
82
34
23
20
18
17
16
15
14
6
4
4
4
4
3
3
3
2
2
1
1
宿主

1321
1113
7
3
3
1
1
1
克隆类型
多克隆
标记
This p53 antibody is un-conjugated
78
76
63
53
45
44
30
30
25
25
25
24
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24
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23
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18
14
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14
14
14
12
7
5
5
5
5
5
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5
4
3
2
2
2
应用范围
Chromatin Immunoprecipitation (ChIP), ELISA, Western Blotting (WB)
1856
745
719
715
614
596
424
340
300
179
72
41
32
31
18
16
15
15
13
9
9
4
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Supplier
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Available images

免疫原 The immunogen is a synthetic peptide directed towards the N terminal region of human TP53
Blocking Peptide Blocking peptide for this product available: ABIN985385
序列 EEPQSDPSVE PPLSQETFSD LWKLLPENNV LSPLPSQAMD DLMLSPDDIE
预测反应 Human: 100%
产品特性 This is a rabbit polyclonal antibody against TP53. It was validated on Western Blot using a cell lysate as a positive control.
纯化方法 Affinity Purified
别名 TP53 (TP53 Antibody 摘要)
背景 TP53 acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
Alias Symbols: LFS1, TRP53, p53
Protein Size: 393
分子量 44 kDa
基因ID 7157
NCBI登录号 NM_000546, NP_000537
UniProt P04637
途径 p53 Pathway, MAPK Pathway, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy
应用备注 Optimal working dilutions should be determined experimentally by the investigator.
说明

Antigen size: 393 AA

限制 仅限研究用
状态 Liquid
浓度 Lot specific
缓冲液 Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
厂商提供的图像
Western Blotting (WB) image for anti-p53 抗体 (Tumor Protein P53) (N-Term) (ABIN2779330) WB Suggested Anti-TP53 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
Western Blotting (WB) image for anti-p53 抗体 (Tumor Protein P53) (N-Term) (ABIN2779330) WB Suggested Anti-TP53 Antibody
Titration: 1 ug/ml
Positive C...
背景 Boehme, Kulikov, Blattner: "p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 22, pp. 7785-90, 2008 (PubMed).