MCTS1 抗体 (N-Term)
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- 抗原 See all MCTS1 抗体
- MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 斑马鱼, 兔
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MCTS1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- MFKKFDEKEN VSNCIQLKTS VIKGIKNQLI EQFPGIEPWL NQIMPKKDPV
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Zebrafish: 86%
- 产品特性
- This is a rabbit polyclonal antibody against MCTS1. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human MCTS1
- Top Product
- Discover our top product MCTS1 Primary Antibody
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anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) antibody
MCTS1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2G2 unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) antibodyMCTS1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) antibodyMCTS1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) antibodyMCTS1 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (C-Term) antibodyMCTS1 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig, 小鸡 IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 1-181) antibodyMCTS1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) antibodyMCTS1 适用: 小鼠, 大鼠 WB, ICC 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 251-350) antibodyMCTS1 适用: 人 WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (AA 251-350) antibody (Alexa Fluor 647)MCTS1 适用: 人 WB, FACS, IF (p), IF (cc) 宿主: 兔 Polyclonal Alexa Fluor 647
anti-Malignant T Cell Amplified Sequence 1 (MCTS1) (N-Term) antibodyMCTS1 适用: 人, 大鼠, 犬, Cow, Pig, 豚鼠, 斑马鱼, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 181 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))
- 别名
- MCTS1 (MCTS1 产品)
- 背景
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MCTS1 is an anti-oncogene that play a role in cell cycle regulation, decreases cell doubling time and anchorage-dependent growth, shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, MCTS1 increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. MCTS1 plays a role as translation enhancer, and recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile, MCTS1 up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. MCTS1 hyperactivates DNA damage signaling pathway, increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. MCTS1 increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when over-expressed in gamma-irradiated cells. MCTS1 may play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. MCTS1 may contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. MCTS1 is involved in the process of proteosome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell, MCTS1 positively regulates phosphorylation of MAPK1 and MAPK3.
Alias Symbols: MCT-1, MCT1
Protein Interaction Partner: ASB6, IPO9, OGFOD1, STK26, UBXN1, ISOC1, TWF2, PROSC, TUBB4B, PDCD6IP, NAE1, USP5, YWHAE, UBA1, PTMA, TWF1, MYO1E, IPO5, HMGB3, HDGF, DHX15, ATIC, UBC, DENR, SUMO1,
Protein Size: 181 - 分子量
- 20 kDa
- 基因ID
- 28985
- NCBI登录号
- NM_014060, NP_054779
- UniProt
- Q9ULC4
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