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PRMT2 抗体 (Protein Arginine Methyltransferase 2) (N-Term)

Details for Product anti-PRMT2 Antibody No. ABIN2778662, 供应商: Log in to see
抗原
  • PRMT2
  • DKFZp459N1919
  • HRMT1L1
  • Hrmt1l1
  • AI504737
  • protein arginine methyltransferase 2
  • protein arginine N-methyltransferase 2
  • PRMT2
  • LOC100356731
  • Prmt2
  • prmt2
Alternatives
anti-大鼠 PRMT2 抗体 for Chromatin Immunoprecipitation
抗原表位
N-Term
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20
6
6
6
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3
3
2
2
1
1
1
1
适用
人, 大鼠
127
17
16
6
4
4
3
3
2
2
2
1
1
宿主

81
33
13
克隆类型
多克隆
标记
This PRMT2 antibody is un-conjugated
6
5
5
5
5
5
1
应用范围
Chromatin Immunoprecipitation (ChIP), Western Blotting (WB)
111
50
33
32
13
10
3
2
2
1
Supplier
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免疫原 The immunogen is a synthetic peptide directed towards the N terminal region of human PRMT2
Blocking Peptide Blocking peptide for this product available: ABIN982232
序列 ERAGCCGYIP ANHVGKHVDE YDPEDTWQDE EYFGSYGTLK LHLEMLADQP
预测反应 Human: 100%, Rat: 79%
产品特性 This is a rabbit polyclonal antibody against PRMT2. It was validated on Western Blot using a cell lysate as a positive control.
纯化方法 Affinity Purified
别名 PRMT2 (PRMT2 Antibody 摘要)
背景 The protein arginine methyltransferases (PRMTs) include a family of proteins with related putative methyltransferase domains that modify chromatin and regulate cellular transcription. PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis and it exerts this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, increasing nuclear IkappaB-alpha and decreasing NF-kappaB DNA binding. PRMT2 also rendered cells susceptible to apoptosis by cytokines or cytotoxic drugs, likely due to its effects on NF-kappaB.
Alias Symbols: HRMT1L1, MGC111373
Protein Interaction Partner: FIP1L1, SPAG8, RIPK2, BAG6, RB1, HNRNPA1, E2F1, UBC, PSMB3, HHV8GK18_gp81, CPSF7, DMRTB1, HNRNPUL1, PRMT2, THRB, PGR, NCOA6, NCOA1, ESR2, RXRA, PRRC2A, ESR1, PPARG, RARA,
Protein Size: 433
分子量 49 kDa
基因ID 3275
NCBI登录号 NM_001535, NP_001526
UniProt P55345
研究领域 Chromatin and Nuclear Signaling
途径 Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding
应用备注 Optimal working dilutions should be determined experimentally by the investigator.
说明

Antigen size: 433 AA

限制 仅限研究用
状态 Liquid
浓度 Lot specific
缓冲液 Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
厂商提供的图像
Western Blotting (WB) image for anti-PRMT2 抗体 (Protein Arginine Methyltransferase 2) (N-Term) (ABIN2778662) WB Suggested Anti-PRMT2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Chromatin Immunoprecipitation (ChIP) image for anti-PRMT2 抗体 (Protein Arginine Methyltransferase 2) (N-Term) (ABIN2778662) Quiescent human colon carcinoma HCT116 cultures were treated with 10 % FBS for three ...
有引用在: Zhong, Cao, Liu, Liu, Wang, Liu, Chen, Yang, Zhang, Wu, Ding, Hong, Xiao, Zu, Wen: "Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein." in: Oncogene, Vol. 33, Issue 48, pp. 5546-58, 2014 (PubMed).

Meyer, Wolf, Obendorf: "PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor." in: The Journal of steroid biochemistry and molecular biology, Vol. 107, Issue 1-2, pp. 1-14, 2007 (PubMed).