Mediator Complex Subunit 6 (MED6) (Middle Region) 抗体

ABIN2778336 产品详细信息, 供应商: Log in to see
抗原
  • NY-REN-28
  • wu:fa14c11
  • zgc:86933
  • 1500012F11Rik
  • AU019660
  • AV213303
  • RNA polymerase transcriptional regulation mediator-related
  • mediator complex subunit 6
  • mediator of RNA polymerase II transcription, subunit 6 homolog (yeast)
  • RNA polymerase II transcriptional regulation mediator
  • AT3G21350
  • MED6
  • Med6
  • med6
抗原表位
Middle Region
15
10
10
9
9
9
9
7
5
2
2
2
1
1
1
适用
牛, 犬, 豚鼠, 马, 人, 小鼠, 猪, 兔, 大鼠
74
15
13
6
5
5
4
4
3
2
1
1
1
1
1
宿主

61
14
克隆类型
多克隆
标记
非结合性
4
4
4
4
4
4
应用范围
Chromatin Immunoprecipitation (ChIP), Western Blotting (WB)
71
38
3
3
2
1
1
1
选项
Supplier
Log in to see
Supplier Product No.
Log in to see
免疫原 The immunogen is a synthetic peptide directed towards the middle region of human MED6
Blocking Peptide Blocking peptide for this product available: ABIN979955
序列 LLLDLRQKFP PKFVQLKPGE KPVPVDQTKK EAEPIPETVK PEEKETTKNV
预测反应 Cow: 93%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 93%
产品特性 This is a rabbit polyclonal antibody against MED6. It was validated on Western Blot using a cell lysate as a positive control.
纯化方法 Affinity Purified
别名 MED6 (MED6 Antibody 摘要)
背景 MED6 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. And mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Alias Symbols: NY-REN-28
Protein Interaction Partner: TARDBP, UBC, CDK19, CDK8, MED10, MED23, CCNC, MED19, MED26, FBXW7, MED11, MED28, MED29, MED4, MED12, MED7, MED21, MED1, SMARCA4, BCL6, SUZ12, CUL1, SKP1, CTDP1, MED25, SREBF1, MED15, VDR, OBFC1, MED18, ZC3H13, TADA2A, RARA, PARP1, SMAD3, SMAD2, SMAD1, MED
Protein Size: 246
分子量 28 kDa
基因ID 10001
NCBI登录号 NM_005466, NP_005457
UniProt O75586
研究领域 Chromatin and Nuclear Signaling, Transcription Factors
途径 Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha
应用备注 Optimal working dilutions should be determined experimentally by the investigator.
说明

Antigen size: 246 AA

限制 仅限研究用
状态 Liquid
浓度 Lot specific
缓冲液 Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
厂商提供的图像
Western Blotting (WB) image for anti-Mediator Complex Subunit 6 (MED6) (Middle Region) antibody (ABIN2778336) WB Suggested Anti-MED6 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
背景 Pavri, Lewis, Kim, Dilworth, Erdjument-Bromage, Tempst, de Murcia, Evans, Chambon, Reinberg: "PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator." in: Molecular cell, Vol. 18, Issue 1, pp. 83-96, 2005 (PubMed).

您还需要查找其他产品吗?