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LIG4 抗体 (N-Term)

LIG4 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2778272
发货至: 中国
  • 抗原 See all LIG4 抗体
    LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))
    抗原表位
    • 15
    • 8
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠
    宿主
    • 60
    • 2
    克隆类型
    • 50
    • 12
    多克隆
    标记
    • 27
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LIG4 antibody is un-conjugated
    应用范围
    • 35
    • 13
    • 13
    • 13
    • 11
    • 11
    • 9
    • 5
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    DGERMQMHKD GDVYKYFSRN GYNYTDQFGA SPTEGSLTPF IHNAFKADIQ
    预测反应
    Cow: 92%, Dog: 93%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 92%, Rabbit: 93%, Rat: 93%
    产品特性
    This is a rabbit polyclonal antibody against LIG4. It was validated on Western Blot and immunohistochemistry.
    纯化方法
    Protein A purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human LIG4
    Top Product
    Discover our top product LIG4 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 911 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))
    别名
    LIG4 (LIG4 产品)
    别名
    zgc:165595 antibody, lig4 antibody, DNA LIGASE IV antibody, LIG4 antibody, lig4-A antibody, 5830471N16Rik antibody, tiny antibody, DNL4 antibody, ligase IV, DNA, ATP-dependent antibody, DNA ligase 4 antibody, ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining antibody, DNA ligase IV antibody, ligase IV, DNA, ATP-dependent L homeolog antibody, lig4 antibody, LIG4 antibody, LOC100212302 antibody, CpipJ_CPIJ005161 antibody, PTRG_09982 antibody, MCYG_05151 antibody, LOC657210 antibody, ATLIG4 antibody, lig4.L antibody, Lig4 antibody
    背景
    LIG4 encodes a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome.
    Protein Interaction Partner: XRCC4, UBC, AGO2, GZMK, ZSCAN18, PHF10, PNKP, TSFM, PRKDC, GUSBP3, NOMO3, FBLL1, PGP, ASPM, AMZ2P1, PPP1R18, COMMD1, ZNF428, AGAP4, WDR20, RPS19BP1, ZFAND2A, FIP1L1, CCDC176, VKORC1, COA7, SOWAHC, SEMA4G, ALMS1, WARS, UBE2L3, UBB, TPT1, TPI1, TP53BP1, TLE
    Protein Size: 911
    分子量
    104 kDa
    基因ID
    3981
    NCBI登录号
    NM_002312, NP_002303
    UniProt
    Q8IY66
    途径
    DNA Damage Repair, Production of Molecular Mediator of Immune Response
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