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BDNF 抗体 (Brain-Derived Neurotrophic Factor) (Middle Region)

Details for Product anti-BDNF Antibody No. ABIN2777093, 供应商: Log in to see
抗原
  • bdnf-A
  • BDNF
  • Bdnf
  • bdnf
  • ANON2
  • BULN2
  • brain-derived neurotrophic factor
  • brain derived neurotrophic factor
  • brain-derived neurotrophic factor-like
  • bdnf
  • bdnf-A
  • BDNF
  • Bdnf
  • bdnf-b
  • LOC100356949
Alternatives
anti-人 BDNF 抗体 for Immunofluorescence (fixed cells)
抗原表位
Middle Region
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适用
犬, 马, 人, 小鼠, 猪, 兔, 大鼠
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宿主

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克隆类型
多克隆
标记
This BDNF antibody is un-conjugated
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应用范围
Immunohistochemistry (IHC), Western Blotting (WB)
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Supplier
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免疫原 The immunogen is a synthetic peptide directed towards the middle region of human BDNF
Blocking Peptide Blocking peptide for this product available: ABIN973798
序列 EWVTAADKKT AVDMSGGTVT VLEKVPVSKG QLKQYFYETK CNPMGYTKEG
预测反应 Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
产品特性 This is a rabbit polyclonal antibody against BDNF. It was validated on Western Blot using a cell lysate as a positive control.
纯化方法 Affinity Purified
别名 BDNF (BDNF Antibody 摘要)
背景 BDNF is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression BDNF is reduced in both Alzheimer's and Huntington disease patients. BDNF may play a role in the regulation of stress response and in the biology of mood disorders.The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene, but the full-length nature of only some could be determined.
Alias Symbols: MGC34632
Protein Interaction Partner: UBC, AGO3, INPP5K, F11R, JUNB, APP, ELAVL1, Ntrk2, CADPS2, MBTPS1, SORT1, NOS3, NTF4, NTF3, ESR1, NCAM1, CPE, BDNF,
Protein Size: 247
分子量 27 kDa
基因ID 627
NCBI登录号 NM_001709, NP_001700
UniProt P23560
研究领域 Cardiovascular, Atherosclerosis, Alzheimer's Disease, Hormones
途径 RTK signaling, Synaptic Membrane, Feeding Behaviour, Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity
应用备注 Optimal working dilutions should be determined experimentally by the investigator.
说明

Antigen size: 247 AA

限制 仅限研究用
状态 Liquid
浓度 Lot specific
缓冲液 Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
厂商提供的图像
Western Blotting (WB) image for anti-BDNF 抗体 (Brain-Derived Neurotrophic Factor) (Middle Region) (ABIN2777093) anti-Brain-Derived Neurotrophic Factor (BDNF) (Middle Region) antibody
Immunohistochemistry (IHC) image for anti-BDNF 抗体 (Brain-Derived Neurotrophic Factor) (Middle Region) (ABIN2777093) anti-Brain-Derived Neurotrophic Factor (BDNF) (Middle Region) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-BDNF 抗体 (Brain-Derived Neurotrophic Factor) (Middle Region) (ABIN2777093) anti-Brain-Derived Neurotrophic Factor (BDNF) (Middle Region) antibody (Image 3)
有引用在: Vassoler, White, Schmidt, Sadri-Vakili, Pierce: "Epigenetic inheritance of a cocaine-resistance phenotype." in: Nature neuroscience, Vol. 16, Issue 1, pp. 42-7, 2012 (PubMed).

McCarthy, Zhang, Darnell, Sangrey, Yanagawa, Sadri-Vakili, Bhide: "Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrain." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 38, pp. 13400-11, 2011 (PubMed).

背景 Hashimoto, Moriguchi, Yamashita, Mori, Nemoto, Okada, Hori, Noguchi, Kunugi, Ohnishi: "Dose-dependent effect of the Val66Met polymorphism of the brain-derived neurotrophic factor gene on memory-related hippocampal activity." in: Neuroscience research, Vol. 61, Issue 4, pp. 360-7, 2008 (PubMed).