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ZIC2 抗体 (C-Term)

ZIC2 适用: 人, 大鼠, 小鼠, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2776475
发货至: 中国
  • 抗原 See all ZIC2 抗体
    ZIC2
    抗原表位
    • 15
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 18
    • 15
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 大鼠, 小鼠, 豚鼠
    宿主
    • 31
    • 2
    • 1
    克隆类型
    • 32
    • 2
    多克隆
    标记
    • 11
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ZIC2 antibody is un-conjugated
    应用范围
    • 23
    • 13
    • 13
    • 8
    • 7
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    EPQSSSNLSP AAAAAAAAAA AAAAAVSAVH RGGGSGSGGA GGGSGGGSGS
    预测反应
    Guinea Pig: 87%, Human: 100%, Mouse: 85%, Rat: 92%
    产品特性
    This is a rabbit polyclonal antibody against ZIC2. It was validated on Western Blot and immunohistochemistry.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the C terminal region of human ZIC2
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 532 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Toth, Schiffmann, Hube-Magg, Büscheck, Höflmayer, Weidemann, Lebok, Fraune, Minner, Schlomm, Sauter, Plass, Assenov, Simon, Meiners, Gerhäuser: "Random forest-based modelling to detect biomarkers for prostate cancer progression." in: Clinical epigenetics, Vol. 11, Issue 1, pp. 148, (2020) (PubMed).

    Inaguma, Ito, Riku, Ikeda, Kasai: "Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2." in: Oncotarget, Vol. 6, Issue 29, pp. 28257-68, (2015) (PubMed).

    Zhu, Wang, He, Huang, Du, Zhang, Yan, Xia, Ye, Wang, Hao, Wu, Fan: "ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells." in: The Journal of clinical investigation, Vol. 125, Issue 10, pp. 3795-808, (2015) (PubMed).

    McCampbell, Truong, Broom, Allchorne, Gable, Cutler, Mattson, Woolf, Frosch, Harmon, Dunn, Brown: "Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy." in: Human molecular genetics, Vol. 14, Issue 22, pp. 3507-21, (2005) (PubMed).

  • 抗原
    ZIC2
    别名
    ZIC2 (ZIC2 产品)
    别名
    HPE5 antibody, Ku antibody, cb851 antibody, fb26a03 antibody, wu:fb26a03 antibody, zic2 antibody, zic2.1 antibody, hpe5 antibody, hm:zeh0655 antibody, id:ibd5017 antibody, zic2.2 antibody, zic2l antibody, Zic family member 2 antibody, zinc finger protein of the cerebellum 2 antibody, zic family member 2 (odd-paired homolog, Drosophila), a antibody, Zic family member 2 L homeolog antibody, zic family member 2 (odd-paired homolog, Drosophila) b antibody, ZIC2 antibody, Zic2 antibody, zic2a antibody, zic2.L antibody, zic2b antibody
    背景
    ZIC2 is a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects.This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
    Alias Symbols: HPE5
    Protein Interaction Partner: SUMO1, ELAVL1, GLI3, GLI2, GLI1, RNF180, UBC,
    Protein Size: 532
    分子量
    55 kDa
    基因ID
    7546
    NCBI登录号
    NM_007129, NP_009060
    UniProt
    O95409
    途径
    Tube Formation
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