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GAPVD1 抗体 (N-Term)

GAPVD1 适用: 人, 小鼠, 犬, 大鼠, Cow, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2775423
发货至: 中国
  • 抗原 See all GAPVD1 抗体
    GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
    抗原表位
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 24
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 犬, 大鼠, Cow, 豚鼠, 马, 兔, 斑马鱼
    宿主
    • 23
    • 2
    克隆类型
    • 25
    多克隆
    标记
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This GAPVD1 antibody is un-conjugated
    应用范围
    • 23
    • 13
    • 13
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    FKLFSEGLFS AKLFLTATLH EPIMQLLVED EDHLETDPNK LIERFSPSQQ
    预测反应
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
    产品特性
    This is a rabbit polyclonal antibody against GAPVD1. It was validated on Western Blot and immunohistochemistry.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human GAPVD1
    Top Product
    Discover our top product GAPVD1 Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 1487 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
    别名
    GAPVD1 (GAPVD1 产品)
    别名
    zgc:92666 antibody, GAPEX5 antibody, RAP6 antibody, 2010005B09Rik antibody, 4432404J10Rik antibody, AW108497 antibody, Gapex-5 antibody, RME-6 antibody, mKIAA1521 antibody, RGD1307479 antibody, GTPase activating protein and VPS9 domains 1 antibody, GTPase activating protein and VPS9 domains 1 S homeolog antibody, LOAG_00609 antibody, GAPVD1 antibody, gapvd1 antibody, gapvd1.S antibody, Gapvd1 antibody
    背景
    GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
    Alias Symbols: DKFZP434C212, KIAA1521, MGC138847, MGC138848, RAP6, GAPEX5
    Protein Interaction Partner: UBC, FOXK1, LRRC47, SF3A1, HNRNPR, IQGAP1, CCDC6, NR3C1, YWHAB, COPS2, SIRT7, ELAVL1, VAV2, RAD21, Csnk1e, CBL,
    Protein Size: 1487
    分子量
    166 kDa
    基因ID
    26130
    NCBI登录号
    NM_015635, NP_056450
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