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DR3/LARD 抗体

TNFRSF25 适用: 人 FACS 宿主: 小鼠 Monoclonal JD3 unconjugated
产品编号 ABIN2749178
发货至: 中国
  • 抗原 See all DR3/LARD (TNFRSF25) 抗体
    DR3/LARD (TNFRSF25) (Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))
    适用
    • 81
    • 28
    • 22
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    • 2
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    宿主
    • 74
    • 9
    小鼠
    克隆类型
    • 73
    • 9
    单克隆
    标记
    • 39
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    • 2
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    This DR3/LARD antibody is un-conjugated
    应用范围
    • 73
    • 35
    • 26
    • 26
    • 9
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    • 1
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    Flow Cytometry (FACS)
    特异性
    The mouse monoclonal antibody JD3 recognizes an extracellular epitope of DR3 (APO-3, TNFRSF25), a transmembrane protein of TNFR superfamily expressed mainly in lymphocyte-enriched tissues.
    交叉反应 (详细)
    Human
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    human DR3-Ig fusion protein
    克隆位点
    JD3
    亚型
    IgG1
    Top Product
    Discover our top product TNFRSF25 Primary Antibody
  • 应用备注
    Flow cytometry: Recommended dilution: 1-4 μg/mL.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • Cavallini, Lovato, Bertolaso, Pacelli, Zoratti, Zanolin, Krampera, Zamò, Tecchio, Cassatella, Pizzolo, Scupoli: "The TNF-family cytokine TL1A inhibits proliferation of human activated B cells." in: PLoS ONE, Vol. 8, Issue 4, pp. e60136, (2013) (PubMed).

    Yi, Zhang, Schwartz-Albiez, Cao: "Mechanisms of the apoptosis induced by CD176 antibody in human leukemic cells." in: International journal of oncology, Vol. 38, Issue 6, pp. 1565-73, (2011) (PubMed).

    Jones, Stumhofer, Foster, Twohig, Hertzog, Topley, Williams, Hunter, Jenkins, Wang, Jones: "Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 25, Issue 1, pp. 409-19, (2011) (PubMed).

    Nakayama, Ishidoh, Kayagaki, Kojima, Yamaguchi, Nakano, Kominami, Okumura, Yagita: "Multiple pathways of TWEAK-induced cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 2, pp. 734-43, (2002) (PubMed).

  • 抗原
    DR3/LARD (TNFRSF25) (Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))
    别名
    DR3 / TRAMP (TNFRSF25 产品)
    别名
    APO-3 antibody, DDR3 antibody, DR3 antibody, LARD antibody, TNFRSF12 antibody, TR3 antibody, TRAMP antibody, WSL-1 antibody, WSL-LR antibody, Tnfrsf12 antibody, Wsl antibody, TNFRSF25 antibody, TNF receptor superfamily member 25 antibody, tumor necrosis factor receptor superfamily, member 25 antibody, TNFRSF25 antibody, Tnfrsf25 antibody
    背景
    TNF receptor superfamily member 25,DR3, also known as APO-3, TRAMP or TNFRSF25, is a death domain-containing receptor of TNFR family, which is expressed preferentially in peripheral blood leukocytes and in the lymphocyte-enriched tissues. Its expression has been shown to be especially up-regulated in activated T cells. DR3 participates e.g. in the removal of self-reactive T cells in the thymus. The ligand for DR3 is TL1A (TNF-like ligand 1A), which is expressed in a variety of cell types (induced by inflammatory stimuli), and can also be released as a soluble factor. The TL1A/DR3 axis has been shown to costimulate T cells to produce a wide variety of cytokines and leads to T cell differentiation towards Th1 and Th17 types.,TNFRSF25, TR3, DDR3, LARD, APO-3, TRAMP, WSL-1, WSL-LR, TNFRSF12
    基因ID
    8718
    UniProt
    Q93038
    途径
    Apoptosis
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