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CD161 抗体 (PE)

KLRB1 适用: 大鼠 FACS 宿主: 小鼠 Monoclonal 10-78 PE
产品编号 ABIN2749047
发货至: 中国
  • 抗原 See all CD161 (KLRB1) 抗体
    CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))
    适用
    • 48
    • 14
    • 6
    • 3
    • 2
    • 2
    大鼠
    宿主
    • 43
    • 17
    小鼠
    克隆类型
    • 42
    • 18
    单克隆
    标记
    • 26
    • 9
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    This CD161 antibody is conjugated to PE
    应用范围
    • 40
    • 24
    • 12
    • 10
    • 10
    • 8
    • 5
    • 4
    • 2
    • 1
    • 1
    Flow Cytometry (FACS)
    特异性
    The mouse monoclonal antibody 10/78 recognizes CD161, an approximately 30 kDa type II transmembrane C-type lectin receptor, expressed on the plasma membrane of NK cells, dendritic cells, activated monocytes and a subset of T cells as a disulphide-linked homodimer. A common extracellular epitope on rat CD161a and b isoforms is detected.
    交叉反应 (详细)
    Rat
    纯化方法
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    免疫原
    Splenic cells purified from the LEW rat
    克隆位点
    10-78
    亚型
    IgG1 kappa
    Top Product
    Discover our top product KLRB1 Primary Antibody
  • 应用备注
    Flow cytometry: Recommended dilution: 1-5 μg/mL.
    说明

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Chang, Tai, Roffler, Hwang: "The immunization site of cytokine-secreting tumor cell vaccines influences the trafficking of tumor-specific T lymphocytes and antitumor efficacy against regional tumors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 10, pp. 6025-32, (2004) (PubMed).

    Stephens, Barclay, Mason: "Phenotypic characterization of regulatory CD4+CD25+ T cells in rats." in: International immunology, Vol. 16, Issue 2, pp. 365-75, (2004) (PubMed).

    May, Dorris, Satumtira, Iqbal, Rehman, Lightfoot, Taurog: "CD8 alpha beta T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 1099-105, (2003) (PubMed).

    Tliba, Chauvin, Le Vern, Boulard, Sbille: "Evaluation of the hepatic NK cell response during the early phase of Fasciola hepatica infection in rats." in: Veterinary research, Vol. 33, Issue 3, pp. 327-32, (2002) (PubMed).

    Sedgwick, Ford, Foulcher, Airriess: "Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blasts." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 11, pp. 5320-30, (1998) (PubMed).

    Kraus, Lambracht, Wonigeit, Hünig: "Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition." in: European journal of immunology, Vol. 26, Issue 11, pp. 2582-6, (1997) (PubMed).

  • 抗原
    CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))
    别名
    CD161 (KLRB1 产品)
    别名
    NKR-P1 antibody, KLRB1 antibody, 4930431A04Rik antibody, Gm4696 antibody, Klrb1g antibody, Klrb6 antibody, Ly-55 antibody, Ly55 antibody, NKR-P1G antibody, Nkrp-1e antibody, Nkrp1g antibody, CD161 antibody, CLEC5B antibody, NKR antibody, NKR-P1A antibody, NKRP1A antibody, hNKR-P1A antibody, Klrb1d antibody, Klrb1f antibody, Nkr-p1e antibody, killer cell lectin like receptor B1 antibody, killer cell lectin-like receptor subfamily B member 1 antibody, killer cell lectin-like receptor subfamily B, member 1 antibody, KLRB1 antibody, Klrb1 antibody
    背景
    Killer cell lectin-like receptor subfamily B, memb,CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.,NKRP1A, Klrb
    基因ID
    689817
    UniProt
    Q0ZUP0
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