CABLES1 抗体
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- 抗原 See all CABLES1 抗体
- CABLES1 (Cdk5 and Abl Enzyme Substrate 1 (CABLES1))
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CABLES1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This antibody detects endogenous levels of Cables1 protein. (region surrounding Lys588)
- 交叉反应 （详细）
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Species reactivity (expected):Mouse.
Species reactivity (tested):Human. - 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
- 纯度
- > 95 % pure by SDS-PAGE
- Top Product
- Discover our top product CABLES1 Primary Antibody
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anti-Cdk5 and Abl Enzyme Substrate 1 (CABLES1) (AA 1-368) antibody
CABLES1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cdk5 and Abl Enzyme Substrate 1 (CABLES1) (C-Term) antibodyCABLES1 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cdk5 and Abl Enzyme Substrate 1 (CABLES1) (C-Term) antibodyCABLES1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Cdk5 and Abl Enzyme Substrate 1 (CABLES1) (C-Term) antibodyCABLES1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cdk5 and Abl Enzyme Substrate 1 (CABLES1) antibodyCABLES1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cdk5 and Abl Enzyme Substrate 1 (CABLES1) (C-Term) antibodyCABLES1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1,0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- DO NOT FREEZE!
- 储存条件
- 4 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C.
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- 抗原
- CABLES1 (Cdk5 and Abl Enzyme Substrate 1 (CABLES1))
- 别名
- CABLES1 (CABLES1 产品)
- 别名
- CABLES1 antibody, si:dkey-2p18.3 antibody, CABL1 antibody, CABLES antibody, HsT2563 antibody, IK3-1 antibody, Cables antibody, ik3-1 antibody, Cdk5 and Abl enzyme substrate 1 antibody, CDK5 and Abl enzyme substrate 1 antibody, CABLES1 antibody, cables1 antibody, CpipJ_CPIJ019832 antibody, Cables1 antibody
- 背景
- Normal Abl function is essential for humans because Philadelphia chromosome translocation involving the ABL gene causes chronic myelogenous leukemia. Abl associates with a broad range of targets and appears to function in various signaling pathways. Cables, a 568 amino-acid protein, links Abl to cyclin-dependent kinase 5 (Cdk5). Cables bound to Cdk5 functions as a substrate for phosphorylation by the Cdk5/p35 kinase. Cables contains an area of weak homology to cyclin A and cyclin C. In addition to its C-terminal Cdk5 binding domain, Cables also has six potential SH3 binding motifs (PXXP) clustered around the amino terminus, two of which are similar to motifs known to bind the Abl SH3 domain. Cables forms a trimolecular complexwith Cdk5 and Abl in vivo. All three proteins colocalize within cortical axons, particularly in their growth cones. Cables and Abl may function as adaptor or scaffolding proteins to bind to Cdk5 and control its subcellular location in the neuron.Synonyms: CDK5 and ABL1 enzyme substrate 1, Ik3-1, Interactor with CDK3 1
- 分子量
- approx. 67 kDa
- 基因ID
- 91768
- NCBI登录号
- NP_001094089
- UniProt
- Q8TDN4
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