Neutrophil Cytosolic Factor 4, 40kDa (NCF4) 抗体

ABIN272048 产品详细信息, 供应商: Log in to see
抗原
  • p40phox
  • AI451400
  • NCF
  • P40PHOX
  • SH3PXD4
  • p40phox protein
  • neutrophil cytosolic factor 4
  • neutrophil cytosolic factor 4, 40kDa
  • p40phox
  • LOC100136241
  • Ncf4
  • NCF4
适用
人, 小鼠
117
57
44
7
7
5
4
4
3
3
宿主

90
20
11
克隆类型
多克隆
标记
非结合性
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
应用范围
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
75
41
33
26
22
5
4
3
3
2
2
1
选项
Supplier
Log in to see
Supplier Product No.
Log in to see
特异性 This antibody detects endogenous levels of p40 phox protein. (region surrounding Arg149)
交叉反应 (详细) Species reactivity (tested):Human, Mouse.
纯化方法 The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
纯度 > 95 % pure by SDS-PAGE
别名 NCF-4 (NCF4 Antibody 摘要)
背景 Nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase is a multimeric enzyme system that mediates electron transport from NADPH in the cytoplasm to molecular oxygen in the phagosome, thereby generating reactive oxidant intermediates. Upon neutrophil stimulation, NADPH-oxidase and other cytosolic elements localize to the cell membrane from the cytosol to form a complex which produces phagocytic oxygen radicals. There are a number of cytosolic proteins that are involved in NADPH-oxidase activation/deactivation,including p47-phox, p67-phox, p40-phox and the small GTP-binding protein, Rac. Activation of NADPH oxidase is accompanied by the phosphorylation of cytosolic components p40-phox, p47-phox and p67-phox. The PKC consensus phosphorylation sites Thr 154 and Ser 315 in p40-phox are phosphorylated during activation of NADPH oxidase. p40-phox can promote oxidase activation by increasing the affinity of p47-phox for NADPH-oxidase. However, p40-phox appears to downregulate oxidase function as well, by competing with an SH3 domain interaction between other essential oxidase components.Synonyms: Neutrophil NADPH oxidase factor 4, Neutrophil cytosol factor 4, SH3 and PX domain-containing protein 4, SH3PXD4, p40-phox
分子量 approx. 39 kDa
基因ID 4689
NCBI登录号 NP_000622
UniProt Q15080
应用备注 ELISA: 1: 10000approx. 1: 20000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 仅限研究用
浓度 1,0 mg/mL
缓冲液 Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
储存液 Sodium azide
注意事项 This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 DO NOT FREEZE!
储存条件 4 °C
储存方法 Store the antibody undiluted at 2-8 °C.
厂商提供的图像
 image for anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) antibody (ABIN272048) anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) antibody
您还需要查找其他产品吗?