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ITGA2 抗体

ITGA2 适用: 小鼠 FACS, IP, BR 宿主: Armenian Hamster Monoclonal HMalpha2 unconjugated
产品编号 ABIN2689302
发货至: 中国
  • 抗原 See all ITGA2 抗体
    ITGA2 (Integrin alpha 2 (ITGA2))
    适用
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    小鼠
    宿主
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    Armenian Hamster
    克隆类型
    • 81
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    单克隆
    标记
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    This ITGA2 antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Reagent (BR)
    品牌
    BD Pharmingen™
    产品特性
    The HMα2 antibody reacts with integrin α2 chain (CD49b), the 150- kDa transmembrane glycoprotein that non-covalently associates with the integrin β1 subunit (CD29) to form the integrin α2β1 complex known as VLA-2. VLA-2, a receptor for collagen and laminin, is expressed on some splenic CD4+ T lymphocytes and NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, splenic NK cells, epithelial cells, and platelets, but it is not on thymocytes or Peyer's-patch or lymphnode lymphocytes. The expression of VLA-2 is upregulated on lymphocytes in response to mitogens. The HMα2 antibody has been reported to partially block the interaction of T-cell blasts, but not NK cells, with collagen. Purified HMα2 mAb blocks the staining of splenic NK cells by the anti-CD49b/Pan-NK Cells mAb DX5 (Cat. No. 553858, for the PE conjugate). Therefore, mAb HMα2 may be used like the DX5 mAb for identification of NK cells. Two-color analysis of CD49b expression on spleen leukocytes. C57BL/6 splenocytes were simultaneously stained with FITC-conjugated mAb M1/70 (anti-mouse CD11b, Cat. No. 557396/553310, both panels) and either purified hamster IgG1, κ isotype control mAb A19-3 (Cat. No. 553969, left panel) or purified HMα2 mAb (right panel), followed by PE-conjugated anti-hamster IgG mAb cocktail (Cat. No. 554056, both panels). Flow cytometry was performed on a BD FACScan™ Flow Cytometry System.

    BD Pharmingen™ Purified Hamster Anti-Mouse CD49b - Purified - Clone HMα2 - Isotype Armenian Hamster IgG1, κ - Reactivity Ms - 0.5 mg
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Mouse colon carcinoma cell line Colon26
    克隆位点
    HMalpha2
    亚型
    IgG1 kappa
    Top Product
    Discover our top product ITGA2 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C.
  • Arase, Saito, Phillips, Lanier: "Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 3, pp. 1141-4, (2001) (PubMed).

    Chen, Paul: "A population of CD62Llow Nk1.1- CD4+ T cells that resembles NK1.1+ CD4+ T cells." in: European journal of immunology, Vol. 28, Issue 10, pp. 3172-82, (1998) (PubMed).

    Tanaka, Ohtsuka, Yagita, Shiratori, Omata, Okumura: "Involvement of alpha 1 and alpha 4 integrins in gut mucosal injury of graft-versus-host disease." in: International immunology, Vol. 7, Issue 8, pp. 1183-9, (1996) (PubMed).

    Noto, Kato, Okumura, Yagita: "Identification and functional characterization of mouse CD29 with a mAb." in: International immunology, Vol. 7, Issue 5, pp. 835-42, (1995) (PubMed).

    Miyake, Sakurai, Okumura, Yagita: "Identification of collagen and laminin receptor integrins on murine T lymphocytes." in: European journal of immunology, Vol. 24, Issue 9, pp. 2000-5, (1994) (PubMed).

  • 抗原
    ITGA2 (Integrin alpha 2 (ITGA2))
    别名
    CD49b (ITGA2 产品)
    别名
    BR antibody, CD49B antibody, GPIa antibody, HPA-5 antibody, VLA-2 antibody, VLAA2 antibody, DX5 antibody, integrin subunit alpha 2 antibody, integrin alpha 2 antibody, ITGA2 antibody, Itga2 antibody
    背景
    Synonyms: Integrin α2 chain
    途径
    CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Integrin Complex
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