(4 references)-
- 抗原 See all NCR1 抗体
- NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This NCR1 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS)
- 品牌
- BD Pharmingen™
- 产品特性
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The 9E2/Nkp46 monoclonal antibody specifically binds to CD335. CD335 is also known as the Natural killer cell p46-related protein (NKp46) and the Natural cytotoxicity triggering receptor 1 (NCR1). CD335 is a 46 kDa type I membrane glycoprotein that is expressed on resting and activated NK cells. Its extracellular region contains two C2-type, Ig-like domains. The transmembrane domain contains a positively charged amino acid (Arg) which could be involved in stabilizing the association with CD3ζ. Its intracellular region does not contain immunoreceptor tyrosine-based activating motifs (ITAM), but it is linked to intracytoplasmic transduction machinery by its association with CD3ζ and FcεRIγ adaptor proteins. CD335 along with NKp30 and NKp44 are referred to as natural cytotoxicity receptors (NCR). These receptors play very important roles in cells that kill virus-infected target cells, tumor cells and MHC-class I-unprotected cells. Profile of CD335 (NKp46) reactivity on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.
BD Pharmingen™ Purified Mouse Anti-Human CD335 (NKp46) - Purified - Clone 9E2/NKp46 (also known as 9-E2) - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 克隆位点
- 9E2-NKp46
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product NCR1 Primary Antibody
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anti-Natural Cytotoxicity Triggering Receptor 1 (NCR1) (AA 198-206) antibody
NCR1 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Natural Cytotoxicity Triggering Receptor 1 (NCR1) (AA 22-258) antibodyNCR1 适用: 人 WB, ELISA, FACS, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 2G3C1 unconjugated
anti-Natural Cytotoxicity Triggering Receptor 1 (NCR1) (AA 17-258) antibodyNCR1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Natural Cytotoxicity Triggering Receptor 1 (NCR1) (Internal Region) antibodyNCR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Natural Cytotoxicity Triggering Receptor 1 (NCR1) (AA 17-211) antibodyNCR1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Natural Cytotoxicity Triggering Receptor 1 (NCR1) (AA 121-230) antibodyNCR1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Natural Cytotoxicity Triggering Receptor 1 (NCR1) antibodyNCR1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Natural Cytotoxicity Triggering Receptor 1 (NCR1) (AA 22-258) antibodyNCR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Natural Cytotoxicity Triggering Receptor 1 (NCR1) antibodyNCR1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Natural Cytotoxicity Triggering Receptor 1 (NCR1) antibodyNCR1 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal n1D9 unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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: "NKp46." in: The international journal of biochemistry & cell biology, Vol. 33, Issue 12, pp. 1147-50, (2001) (PubMed).
: "Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity." in: European journal of immunology, Vol. 30, Issue 11, pp. 3309-18, (2001) (PubMed).
: "NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against ..." in: European journal of immunology, Vol. 29, Issue 5, pp. 1656-66, (1999) (PubMed).
: "p46, a novel natural killer cell-specific surface molecule that mediates cell activation." in: The Journal of experimental medicine, Vol. 186, Issue 7, pp. 1129-36, (1997) (PubMed).
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: "NKp46." in: The international journal of biochemistry & cell biology, Vol. 33, Issue 12, pp. 1147-50, (2001) (PubMed).
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- 抗原
- NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))
- 别名
- CD335 NKp46 (NCR1 产品)
- 别名
- CD335 antibody, LY94 antibody, NK-p46 antibody, NKP46 antibody, Ly94 antibody, NKp46 antibody, KILR-1 antibody, Nk-p46 antibody, Nkp46 antibody, natural cytotoxicity triggering receptor 1 antibody, NCR1 antibody, Ncr1 antibody
- 途径
- Regulation of Leukocyte Mediated Immunity
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