(6 references)-
- 抗原 See all CCR6 抗体
- CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CCR6 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS)
- 品牌
- BD Pharmingen™
- 产品特性
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The monoclonal antibody 11A9 reacts with the human CC chemokine receptor, CCR6. CCR6 (previously known as BN-1, CKR-L3, DRY6, GPR-CY4 and STRL22), a seven-transmembrane, G-protein-coupled receptor, is the specific receptor for CC chemokine MIP-3a/LARC/ Exodus. It has been shown that CCR6 mRNA is expressed mainly in lymphoid tissues including spleen, lymph nodes, thymus, appendix. CCR6 mRNA was also detected in peripheral T- and B-lymphocytes and in CD34-derived dendritic cells. The human CCR6 gene, unlike other CCR genes, has been mapped to chromosome 6q27. The immunogen used to generate 11A9 hybridoma was KLH-conjugated N-terminus peptides of human CCR6. It does not cross-react with human CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CCR8, CCR9, CXCR1, CXCR2, CXCR3, CXCR4 and CXCR5 transfectants. This antibody is NOT a neutralizing antibody. CCR6 had been clustered as CD196 in the VIIIth HLDA workshop. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Expression of human CCR6 on peripheral lymphocytes detected by purified 11A9.
BD Pharmingen™ Purified Mouse Anti-Human CD196 (CCR6) - Purified - Clone 11A9 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.5 mg - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 克隆位点
- 11A9
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product CCR6 Primary Antibody
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anti-Chemokine (C-C Motif) Receptor 6 (CCR6) antibody
CCR6 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 7C6D9 unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (AA 201-300) antibodyCCR6 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (N-Term) antibodyCCR6 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) antibodyCCR6 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (AA 322-374) antibodyCCR6 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (AA 18-46) antibodyCCR6 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (N-Term) antibodyCCR6 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 6 (CCR6) (AA 18-46) antibodyCCR6 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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: "STRL22 is a receptor for the CC chemokine MIP-3alpha." in: Biochemical and biophysical research communications, Vol. 236, Issue 1, pp. 212-7, (1997) (PubMed).
: "Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells." in: The Journal of experimental medicine, Vol. 186, Issue 6, pp. 825-35, (1997) (PubMed).
: "Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC." in: The Journal of biological chemistry, Vol. 272, Issue 23, pp. 14893-8, (1997) (PubMed).
: "CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3alpha and is highly expressed in human dendritic cells." in: The Journal of experimental medicine, Vol. 186, Issue 6, pp. 837-44, (1997) (PubMed).
: "Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27." in: Genomics, Vol. 40, Issue 1, pp. 175-80, (1997) (PubMed).
: "Molecular cloning and RNA expression of two new human chemokine receptor-like genes." in: Biochemical and biophysical research communications, Vol. 227, Issue 3, pp. 846-53, (1996) (PubMed).
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: "STRL22 is a receptor for the CC chemokine MIP-3alpha." in: Biochemical and biophysical research communications, Vol. 236, Issue 1, pp. 212-7, (1997) (PubMed).
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- 抗原
- CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))
- 别名
- CD196 CCR6 (CCR6 产品)
- 背景
- Synonyms: CCR6
- 途径
- cAMP Metabolic Process
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